Inulin based glutathione-responsive delivery system for colon cancer treatment
文献类型：期刊论文
| 作者 | Wang, Dongdong2; Sun, Feifei2; Lu, Chunbo2; Chen, Peng2; Wang, Zhaojie2; Qiu, Yuanhao2; Mu, Haibo2; Miao, Zehong1; Duan, Jinyou2 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2018-05 |
| 卷号 | 111页码:1264-1272 |
| 关键词 | Inulin Lipoic add Polymeric micelles Colorectal cancer Probiotic |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.fibiomac.2018.01.071 |
| 文献子类 | Article |
| 英文摘要 | Colorectal cancer is one of the most common types of tumor in the world. Here we developed a lipoic acid esterified polysaccharide (inulin) delivery system for tanshinone IIA to treat colorectal cancer in vitro. The release of tanshinone IIA in the system was highly responsive to glutathione, which is commonly abundant in cancer cells. In addition, this drug delivery system was proliferative to Bifidobacterium longum, the common inhabitant of human intestine. Thus, this strategy might be useful to improve colon cancer therapy efficacy of anticancer drugs and meanwhile promote the growth of beneficial commensal flora in the gut. (C) 2018 Elsevier B.V. All rights reserved. |
| WOS关键词 | SALVIA-MILTIORRHIZA BUNGE ; TANSHINONE-IIA ; DRUG-DELIVERY ; IN-VITRO ; NANOPARTICLES ; CELLS ; DOXORUBICIN ; PROBIOTICS ; HEPATOMA ; POLYSACCHARIDE |
| 资助项目 | National Natural Science Foundation of China (NSFC)[31570799] ; Fundamental Research Funds for the Central Universities, Northwest AF University[2452017026] ; Fundamental Research Funds for the Central Universities, Northwest AF University[Z109021713] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica[SIMM1203-11] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000429391000143 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279788]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Miao, Zehong; Duan, Jinyou |
| 作者单位 | 1.Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China 2.Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Dongdong,Sun, Feifei,Lu, Chunbo,et al. Inulin based glutathione-responsive delivery system for colon cancer treatment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,111:1264-1272. |
| APA | Wang, Dongdong.,Sun, Feifei.,Lu, Chunbo.,Chen, Peng.,Wang, Zhaojie.,...&Duan, Jinyou.(2018).Inulin based glutathione-responsive delivery system for colon cancer treatment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,111,1264-1272. |
| MLA | Wang, Dongdong,et al."Inulin based glutathione-responsive delivery system for colon cancer treatment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 111(2018):1264-1272. |
入库方式： OAI收割
来源：上海药物研究所
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