Tumor Cells-Selective Bionic Nanodevice Exploiting Heparanase Combats Metastatic Breast Cancer
文献类型：期刊论文
| 作者 | Lang, Tianqun1,2,3; Ran, Wei1,2,3; Dong, Xinyue2,3; Zheng, Zhong2,3; Liu, Yiran2,3; Yin, Qi2,3 ; Li, Yaping2,3
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2018-04-25 |
| 卷号 | 28期号:17 |
| 关键词 | breast cancer heparan sulfate metastasis red blood cell membranes tumor-targeting micelles |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201707289 |
| 文献子类 | Article |
| 英文摘要 | The clinical application of the cytotoxic chemotherapeutic agents in the treatment of metastatic breast cancer is limited by their poor selectivity to cancer cells. In this work, a bionic nanodevice consisting of the docetaxel (DTX)-heparan sulfate (HS) conjugate (HS-DTX) micelle with a red blood cells membrane (RBC) coating on its surface, termed as rHS-DTX, is first constructed. It is found that the cytotoxicity of DTX is concealed by HS in human mammary epithelial Michigan Cancer Foundation (MCF)-10A cells but restored in human mammary cancer MCF-7 cells because HS is hydrolyzed by heparanase (Hpa), which is overexpressed only in MCF-7 but not MCF-10A cells. The RBC coating enhances the cellular uptake of HS-DTX and endows it with the long circulating ability in blood. In the MCF-7 metastatic breast cancer mice model, rHS-DTX exhibits 6.35-fold higher intratumor DTX accumulation than the free DTX injection and achieves a tumor inhibiting rate of 98.2% and a lung metastasis suppression rate of 99.6%. No severe toxicity is observed in the major organs and blood of mice treated with rHS-DTX. In summary, rHS-DTX can provide a promising strategy for targeting therapy of metastatic breast cancer by improving the tumor-suppressing efficacy of DTX. |
| WOS关键词 | INFLAMMATORY MONOCYTES ; LUNG METASTASIS ; DRUG-RELEASE ; IN-VIVO ; NANOPARTICLES ; THERAPY |
| 资助项目 | National Basic Research Program of China[2014CB931900] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81521005] ; Key scientific research program of CAS[QYZDJ-SSW-SMC020] ; Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS)[2015226] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000430658300024 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279795]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yin, Qi; Li, Yaping |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lang, Tianqun,Ran, Wei,Dong, Xinyue,et al. Tumor Cells-Selective Bionic Nanodevice Exploiting Heparanase Combats Metastatic Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(17). |
| APA | Lang, Tianqun.,Ran, Wei.,Dong, Xinyue.,Zheng, Zhong.,Liu, Yiran.,...&Li, Yaping.(2018).Tumor Cells-Selective Bionic Nanodevice Exploiting Heparanase Combats Metastatic Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,28(17). |
| MLA | Lang, Tianqun,et al."Tumor Cells-Selective Bionic Nanodevice Exploiting Heparanase Combats Metastatic Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 28.17(2018). |
入库方式： OAI收割
来源：上海药物研究所
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