Cu-Mediated Sulfonyl Radical-Enabled 5-exo-trig Cyclization of Alkenyl Aldehydes: Access to Sulfonylmethyl 1H-Indenes
文献类型：期刊论文
| 作者 | Ni, Jiabin1,2,3; Xue, Yu2,3,4; Sun, Liping4; Zhang, Ao1,2,3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2018-04-20 |
| 卷号 | 83期号:8页码:4598-4605 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.8b00341 |
| 文献子类 | Article |
| 英文摘要 | An efficient method for the construction of sulfonylmethyl 1H-indenes via Cu(I)-mediated sulfonyl radical enabled 5-exo-trig cyclization of alkenyl aldehydes has been developed for the first time. Mechanistic studies indicated that a radical addition-cyclization-elimination (RACE) process might be involved. The reaction features a relatively broad substrate scope, good annulation efficiency, and varying functional group tolerance. |
| WOS关键词 | CATALYZED CYCLIZATION ; BIOLOGICAL EVALUATION ; CASCADE CYCLIZATION ; INDENE DERIVATIVES ; VINYL SULFONES ; BOND FORMATION ; HYDRAZIDES ; CHEMISTRY ; ALKYNES ; ACIDS |
| 资助项目 | International Cooperative Program[GJHZ1622 2060899] ; Key Program of the Frontier Science of the Chinese Academy of Sciences[QYZDJ-SSW-SMC002] ; National Natural Science Foundation of China[81773565] ; National Natural Science Foundation of China[81430080] ; Shanghai Commission of Science and Technology[16XD140-4600] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000430898500026 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279797]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Sun, Liping; Zhang, Ao |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ni, Jiabin,Xue, Yu,Sun, Liping,et al. Cu-Mediated Sulfonyl Radical-Enabled 5-exo-trig Cyclization of Alkenyl Aldehydes: Access to Sulfonylmethyl 1H-Indenes[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(8):4598-4605. |
| APA | Ni, Jiabin,Xue, Yu,Sun, Liping,&Zhang, Ao.(2018).Cu-Mediated Sulfonyl Radical-Enabled 5-exo-trig Cyclization of Alkenyl Aldehydes: Access to Sulfonylmethyl 1H-Indenes.JOURNAL OF ORGANIC CHEMISTRY,83(8),4598-4605. |
| MLA | Ni, Jiabin,et al."Cu-Mediated Sulfonyl Radical-Enabled 5-exo-trig Cyclization of Alkenyl Aldehydes: Access to Sulfonylmethyl 1H-Indenes".JOURNAL OF ORGANIC CHEMISTRY 83.8(2018):4598-4605. |
入库方式： OAI收割
来源：上海药物研究所
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