A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors
文献类型：期刊论文
| 作者 | Wang, Tingting1,2,3; Wang, Dangge1,2,3; Yu, Haijun1,2 ; Feng, Bing1,2,3; Zhou, Fangyuan1,2; Zhang, Hanwu1,2; Zhou, Lei1,2; Jiao, Shi4; Li, Yaping1,2
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| 刊名 | NATURE COMMUNICATIONS
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| 出版日期 | 2018-04-18 |
| 卷号 | 9 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-03915-4 |
| 文献子类 | Article |
| 英文摘要 | Vaccines to induce effective and sustained antitumor immunity have great potential for postoperative cancer therapy. However, a robust cancer vaccine simultaneously eliciting tumor-specific immunity and abolishing immune resistance continues to be a challenge. Here we present a personalized cancer vaccine (PVAX) for postsurgical immunotherapy. PVAX is developed by encapsulating JQ1 (a BRD4 inhibitor) and indocyanine green (ICG) co-loaded tumor cells with a hydrogel matrix. Activation of PVAX by 808 nm NIR laser irradiation significantly inhibits the tumor relapse by promoting the maturation of dendritic cells and eliciting tumor infiltration of cytotoxic T lymphocytes. A mechanical study reveals that NIR light-triggered antigen release and JQ1-mediated PD-L1 checkpoint blockade cumulatively contribute to the satisfied therapeutic effect. Furthermore, PVAX prepared from the autologous tumor cells induces patient-specific memory immune response to prevent tumor recurrence and metastasis. The PVAX model might provide novel insights for postoperative immunotherapy. |
| WOS关键词 | T-CELLS ; PHOTOTHERMAL THERAPY ; MELANOMA PATIENTS ; IMMUNE-RESPONSES ; NANOPARTICLES ; BLOCKADE ; COMBINATION ; NEOANTIGENS ; ANTIGENS ; IMPROVE |
| 资助项目 | National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000430286800007 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279800]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Tingting,Wang, Dangge,Yu, Haijun,et al. A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors[J]. NATURE COMMUNICATIONS,2018,9. |
| APA | Wang, Tingting.,Wang, Dangge.,Yu, Haijun.,Feng, Bing.,Zhou, Fangyuan.,...&Li, Yaping.(2018).A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.NATURE COMMUNICATIONS,9. |
| MLA | Wang, Tingting,et al."A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors".NATURE COMMUNICATIONS 9(2018). |
入库方式： OAI收割
来源：上海药物研究所
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