Pd-catalyzed intramolecular C(sp(2))-H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides
文献类型：期刊论文
| 作者 | Zheng, Yong; Song, Weibin; Zhu, Yefu; Wei, Bole; Xuan, Lijiang
|
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2018-04-14 |
| 卷号 | 16期号:14页码:2402-2405 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c8ob00207j |
| 文献子类 | Article |
| 英文摘要 | A palladium-catalyzed intramolecular C(sp(2))-H amination of phenylalanine moieties in dipeptides is described. By this protocol, a series of indoline-2-carboxylate-containing dipeptides were synthesized from dipeptides. The N-protected amino acid moiety within the peptide is used as an intrinsic bidentate directing group. This intramolecular C-H amination reaction provides an appealing strategy for the post-synthetic modification of peptides. |
| WOS关键词 | C-H ACTIVATION ; ASYMMETRIC-SYNTHESIS ; DIRECTING GROUP ; PD(II)-CATALYZED AMINATION ; POSTSYNTHETIC MODIFICATION ; FUTURE-DIRECTIONS ; AMINO-ACIDS ; PEPTIDES ; FUNCTIONALIZATION ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[81602995] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000429204000005 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279803]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Lijiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Yong,Song, Weibin,Zhu, Yefu,et al. Pd-catalyzed intramolecular C(sp(2))-H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2018,16(14):2402-2405. |
| APA | Zheng, Yong,Song, Weibin,Zhu, Yefu,Wei, Bole,&Xuan, Lijiang.(2018).Pd-catalyzed intramolecular C(sp(2))-H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides.ORGANIC & BIOMOLECULAR CHEMISTRY,16(14),2402-2405. |
| MLA | Zheng, Yong,et al."Pd-catalyzed intramolecular C(sp(2))-H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides".ORGANIC & BIOMOLECULAR CHEMISTRY 16.14(2018):2402-2405. |
入库方式： OAI收割
来源：上海药物研究所
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