Structural, stereochemical, and bioactive studies of cembranoids from Chinese soft coral &ITSarcophyton trocheliophorum&IT
文献类型：期刊论文
| 作者 | Liang, Lin-Fu3,4; Kurtan, Tibor1; Mandi, Attila1; Yao, Li-Gong3; Li, Jia3 ; Lan, Le-Fu3; Guo, Yue-Wei2,3
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2018-04-12 |
| 卷号 | 74期号:15页码:1933-1941 |
| 关键词 | Sarcophyton trocheliophorum Cembranoid Structure elucidation Absolute configuration Biological activities |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2018.02.059 |
| 文献子类 | Article |
| 英文摘要 | A series of highly oxidative new cembranoids with diverse structural features such as a dienoate moiety (sarcophytonolides S - U, 1-3) or an alpha,beta-unsaturated epsilon-lactone (sartrolides H - J, 4-6) were obtained from Hainan soft coral Sarcophyton trocheliophorum, along with known related analogues 7-13. It is an extremely challenging work to determine the absolute configurations of these metabolites. For compounds 1, 3 and 4, solution TDDFT calculation of ECD and specific rotation were applied in combination with conformational analysis and NMR data to determine their relative and absolute configurations, leading to the revision of relative configuration of 14. The absolute configurations of compounds 8-10 were determined by the solid-state TDDFT-ECD approach, and that of 8 was further confirmed by singlecrystal X-ray diffraction experiment with Cu K alpha radiation. In the bioassays, compound 8 exhibited not only moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activity (IC50 = 15.4 mu M) but also moderate antibacterial activity against Staphylococcus aureus Newman strain (MIC50 = 250 mu M). (C) 2018 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ABSOLUTE-CONFIGURATION ; A-D ; DITERPENOIDS ; SESQUITERPENES ; MARENZELLER ; INHIBITOR ; GENUS |
| 资助项目 | Natural Science Foundation of China[41506187] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SCTSM[15431901000] ; Hunan Provincial Education Department[16C1674] ; SKLDR/SIMM Projects[SIMM 1705ZZ-01] ; EU[00000000] ; European Regional Development Fund[GINOP-2.3.2-15-2016-00008] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000430028400024 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279804]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Kurtan, Tibor; Guo, Yue-Wei |
| 作者单位 | 1.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary 2.Qingdao Natl Lab Marine Sci & Technol, Open Studio Drugabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China; 4.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Hunan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liang, Lin-Fu,Kurtan, Tibor,Mandi, Attila,et al. Structural, stereochemical, and bioactive studies of cembranoids from Chinese soft coral &ITSarcophyton trocheliophorum&IT[J]. TETRAHEDRON,2018,74(15):1933-1941. |
| APA | Liang, Lin-Fu.,Kurtan, Tibor.,Mandi, Attila.,Yao, Li-Gong.,Li, Jia.,...&Guo, Yue-Wei.(2018).Structural, stereochemical, and bioactive studies of cembranoids from Chinese soft coral &ITSarcophyton trocheliophorum&IT.TETRAHEDRON,74(15),1933-1941. |
| MLA | Liang, Lin-Fu,et al."Structural, stereochemical, and bioactive studies of cembranoids from Chinese soft coral &ITSarcophyton trocheliophorum&IT".TETRAHEDRON 74.15(2018):1933-1941. |
入库方式： OAI收割
来源：上海药物研究所
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