中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents

文献类型:期刊论文

作者Jiang, Hao-Wen1,4; Lin, Jing3; Wang, Gui-Min1; Zhang, Jing-Jing1; Gu, Shan-Shan2,3; Cao, Lei3; Chen, Yan3; Wang, Ling3; Jiao, He3; Zhu, Wei-Liang1
刊名PHYTOCHEMISTRY LETTERS
出版日期2018-04
卷号24页码:179-183
ISSN号1874-3900
关键词Cynanchum wilfordii Acetophenone derivatives A beta aggregation Neuroprotective
DOI10.1016/j.phytol.2018.02.002
文献子类Article
英文摘要Seven new acetophenone derivatives, three couples of enantiomers (+/-)-cynwilforones D - F (1 - 3) together with cynwilforone G (4), were isolated form the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and X-ray crystallography. Each racemate was separated into individual enantiomers, and electronic circular dichroism (ECD) calculations were used to assign their absolute configurations. All compounds exhibited inhibitory effect of A beta oligomerization in different degrees. Among them, (+)-3 and (-)-3 showed neuroprotective effects on A beta oligomers-treated SH-SY5Y cells.
WOS关键词AMYLOID-BETA PEPTIDE ; ALZHEIMERS-DISEASE ; A-BETA ; FIBRILS ; AGGREGATION ; OLIGOMERS
资助项目National Natural Science Foundation of China[81273399] ; National Students' platform for innovation and entrepreneurship training program[201710304040] ; State Key Laboratory of Drug Research[SIMM1705KF-04]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER SCIENCE BV
WOS记录号WOS:000432718900036
源URL[http://119.78.100.183/handle/2S10ELR8/279817]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药理学第二研究室
通讯作者Zhang, Hai-Yan; Zhao, Wei-Min; Li, Jin-Long
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Nantong Hosp Tradit Chinese Med, Dept Pharm, Nantong 226001, Peoples R China;
3.Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China;
4.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China;
推荐引用方式
GB/T 7714
Jiang, Hao-Wen,Lin, Jing,Wang, Gui-Min,et al. Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents[J]. PHYTOCHEMISTRY LETTERS,2018,24:179-183.
APA Jiang, Hao-Wen.,Lin, Jing.,Wang, Gui-Min.,Zhang, Jing-Jing.,Gu, Shan-Shan.,...&Li, Jin-Long.(2018).Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents.PHYTOCHEMISTRY LETTERS,24,179-183.
MLA Jiang, Hao-Wen,et al."Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents".PHYTOCHEMISTRY LETTERS 24(2018):179-183.

入库方式: OAI收割

来源:上海药物研究所

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