Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression
文献类型：期刊论文
| 作者 | Zhou, Zhen-Fang2; Li, Xiao-Lu2; Yao, Li-Gong2; Li, Jia2 ; Gavagnin, Margherita1; Guo, Yue-Wei2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 28期号:6页码:1093-1096 |
| 关键词 | Pulmonate Polypropionates Absolute configuration XBP1 |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2018.02.010 |
| 文献子类 | Article |
| 英文摘要 | Two additional new members of the onchidione family, 16-epi-onchidione (1) and 4-epi-onchidione (2), co-occurring with six previously reported bis-gamma-pyrone polypropionates including onchidione (3), were isolated from the marine pulmonate Onchidium sp. Their structures were determined by extensive spectroscopic analysis and by comparison with 3 and onchidione-related derivatives. The absolute configuration of 1 was established by X-ray diffraction analysis employing graphite monochromated Cu K-alpha radiation (lambda = 0.71073 angstrom) with small Flack parameter 0.08. In addition, the absolute stereochemistry of previously reported onchidionol (6) was confirmed by the X-ray diffraction analysis. Some of the isolated compounds showed significant activation effects on the splicing of XBP1 mRNA as ER stress modulators to inhibit the growth of tumors. (C) 2018 Elsevier Ltd. All rights reserved. |
| WOS关键词 | NATURAL-PRODUCTS ; ILIKONAPYRONE ; CHEMISTRY ; ESTERS |
| 资助项目 | Natural Science Foundation of China (NSFC) key international collaboration project[81520108028] ; NSFC[21672230] ; NSFC[41676073] ; NSFC[81473244] ; NSFC-Shandong Joint Fundfor Marine Science Research Centers[U1606403] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM 1705ZZ-01] ; MIUR-ITALY PRIN[2015MSCKCE_003] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000427531500020 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279834]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Gavagnin, Margherita; Guo, Yue-Wei |
| 作者单位 | 1.CNR, ICB, Via Campi Flegrei 34, I-80078 Naples, Italy 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Zuchongzhi Rd 555 Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Zhen-Fang,Li, Xiao-Lu,Yao, Li-Gong,et al. Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(6):1093-1096. |
| APA | Zhou, Zhen-Fang,Li, Xiao-Lu,Yao, Li-Gong,Li, Jia,Gavagnin, Margherita,&Guo, Yue-Wei.(2018).Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(6),1093-1096. |
| MLA | Zhou, Zhen-Fang,et al."Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.6(2018):1093-1096. |
入库方式： OAI收割
来源：上海药物研究所
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