中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 化学蛋白质组学研究中心
Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin

文献类型：期刊论文

作者Jiang, Wei1,11,12; Zhou, Xiaoyan8,9,10; Li, Zengxia12; Liu, Kaiyu12; Wang, Weige8,9,10; Tan, Renke12; Cong, Xiaoji7; Shan, Jiaoyu6; Zhan, Yanxia4,5; Cui, Zhaomeng12
刊名BLOOD
出版日期2018-03-22
卷号131期号:12页码:1325-1336
ISSN号0006-4971
DOI10.1182/blood-2017-07-794875
文献子类Article
英文摘要B-cell lymphomas are heterogeneous blood disorders with limited therapeutic options, largely because of their propensity to relapse and become refractory to treatments. Carabin, a key suppressor of B-cell receptor signaling and proliferation, is inactivated in B-cell lymphoma by unknown mechanisms. Here, we identify prolyl 4-hydroxylase 2 (P4HA2) as a specific proline hydroxylase of Carabin. Carabin hydroxylation leads to its proteasomal degradation, thereby activating the Ras/extracellular signal-regulated kinase pathway and increasing B-cell lymphoma proliferation. P4HA2 is undetectable in normal B cells but upregulated in the diffuse large B-cell lymphoma (DLBCL), driving Carabin inactivation and lymphoma proliferation. Our results indicate that P4HA2 is a potential prognosis marker for DLBCL and a promising pharmacological target for developing treatment of molecularly stratified B-cell lymphomas.
WOS关键词ALPHA-SUBUNIT ISOFORM ; ELDERLY-PATIENTS ; R-CHOP ; RECEPTOR ; PROTEIN ; EXPRESSION ; RAS ; IDENTIFICATION ; CALCINEURIN ; METASTASIS
资助项目National Natural Science Foundation of China[31270830] ; National Natural Science Foundation of China[21572038] ; National Natural Science Foundation of China[81502394] ; National Natural Science Foundation of China[31370814] ; National Natural Science Foundation of China[81470353] ; National Natural Science Foundation of China[81272630] ; National Basic Research Program of China (973 Program)[2014CBA02004] ; Flight Attendant Medical Research Institute[00000000] ; National Institutes of Health National Cancer Institute[P30 CA006973] ; Development Fund for Shanghai Talents[00000000] ; Fund of State Key Laboratory of Bioorganic and Natural Products Chemistry[00000000] ; Fund of State Key Laboratory of Drug Research, Chinese Academy of Sciences[SIMM1601KF-08]
WOS研究方向Hematology
语种英语
WOS记录号WOS:000430687700011
出版者AMER SOC HEMATOLOGY
源URL[http://119.78.100.183/handle/2S10ELR8/279842]  
专题化学蛋白质组学研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Dang, Yongjun
作者单位1.Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA;
2.Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
3.Fudan Univ, Sch Life Sci, Shanghai, Peoples R China;
4.Fudan Univ, Zhongshan Hosp, Biomed Res Ctr, Shanghai, Peoples R China;
5.Fudan Univ, Dept Hematol, Shanghai, Peoples R China;
6.Shanghai Jiao Tong Univ, Sch Med, Dept Immunol & Microbiol, Shanghai Inst Immunol, Shanghai, Peoples R China;
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, Shanghai, Peoples R China;
8.Fudan Univ, Inst Pathol, Shanghai, Peoples R China;
9.Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China;
10.Fudan Univ, Dept Pathol, Shanghai Canc Ctr, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Jiang, Wei,Zhou, Xiaoyan,Li, Zengxia,et al. Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin[J]. BLOOD,2018,131(12):1325-1336.
APA Jiang, Wei.,Zhou, Xiaoyan.,Li, Zengxia.,Liu, Kaiyu.,Wang, Weige.,...&Dang, Yongjun.(2018).Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin.BLOOD,131(12),1325-1336.
MLA Jiang, Wei,et al."Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin".BLOOD 131.12(2018):1325-1336.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。