Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones
文献类型：期刊论文
| 作者 | Yang, Yuanyong1,2; Li, Yingxian1; Cheng, Cheng1; Yang, Guo1; Zhang, Jiquan1,2; Zhang, Yi1,2; Zhao, Yonglong1,2; Zhang, Lin1,2; Li, Chun1,2; Tang, Lei2,3 |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2018-03-16 |
| 卷号 | 83期号:6页码:3348-3353 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.7b02961 |
| 文献子类 | Article |
| 英文摘要 | The palladium-catalyzed cross-coupling reaction of aryl halides with isoquinoline-1,3(2H,4H)-diones for the synthesis of 4-aryl isoquinoline-1,3(2H,4H)-diones was developed. The reaction conditions exhibit remarkable compatibility with various aryl halides and isoquinoline-1,3(2H,4H)-diones, and the product could be conveniently transformed to 4-aryl tetrahydroisoquinolines. (+/-) Dichlorofensine was synthesized using this protocol in two steps with an overall yield of 71%. |
| WOS关键词 | TETRAHYDROISOQUINOLINE ALKALOIDS ; ACTIVATED ALKENES ; C-C ; CHEMISTRY ; ARYLATION |
| 资助项目 | National Natural Science Foundation of China[81660348] ; National Natural Science Foundation of China[81703356] ; National Natural Science Foundation of China[21502030] ; National Natural Science Foundation of China[GMU(J[2014] ; Office of Science & Technology of Guiyang[[20151001] ; Office of Science & Technology of Guizhou[[2015] ; Guizhou Provincial Engineering Technology Research Center for Chemical Drug RD[00000000] ; Guizhou High-School Engineering Research Center for Medicinal Chemistry[KY2014-219] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000428002800037 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279848]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Li, Chun; Tang, Lei |
| 作者单位 | 1.Guizhou Med Univ, Sch Pharm, Guiyang 550004, Guizhou, Peoples R China; 2.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yuanyong,Li, Yingxian,Cheng, Cheng,et al. Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(6):3348-3353. |
| APA | Yang, Yuanyong.,Li, Yingxian.,Cheng, Cheng.,Yang, Guo.,Zhang, Jiquan.,...&Tang, Lei.(2018).Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones.JOURNAL OF ORGANIC CHEMISTRY,83(6),3348-3353. |
| MLA | Yang, Yuanyong,et al."Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones".JOURNAL OF ORGANIC CHEMISTRY 83.6(2018):3348-3353. |
入库方式： OAI收割
来源：上海药物研究所
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