Light-Activated Core-Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer
文献类型：期刊论文
| 作者 | Meng, Qingshuo1,2,3; Meng, Jia1,2,3; Ran, Wei1,2,3; Wang, Junyang1,2,4; Zhai, Yihui1,2,3; Zhang, Pengcheng1,2 ; Li, Yaping1,2
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| 刊名 | ACS NANO
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| 出版日期 | 2018-03 |
| 卷号 | 12期号:3页码:2789-2802 |
| 关键词 | spatiotemporal metastasis triple-negative breast cancer depth photodynamic |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.7b09210 |
| 文献子类 | Article |
| 英文摘要 | Triple-negative breast cancer (TNBC) tumors are heterogeneous, with mesenchymal-like cells at their core and fast proliferating cells on the periphery. It is desirable and beneficial to treat TNBC cells of different phenotypes with the most appropriate drugs. Here, we report a 78 nm, chlorin e6-, docetaxel-, and anti-Twist siRNA-containing polymeric nanoparticle (CDTN) with spatiotemporally specific activity when irradiated by light. Under conditions mimicking superficial tumor tissue with sufficient light input, TNBC cells are mainly killed by the photodynamic therapy (PDT) function of CDTNs. In contrast, under conditions mimicking deep tumor tissue with weak light input, PDT potentiates chemotherapy (CT) and gene therapy (GT) by facilitating the endolysosomal escape of CDTNs. Compared with free drugs, CDTNs improve the intratumoral exposure of docetaxel and anti-Twist siRNA by 2.5- and 2-fold, respectively. When combined with laser irradiation applied at the time of maximal intratumoral accumulation, the CDTNs significantly inhibit the growth of primary tumors and their lung metastasis (both >80%) by killing the peripheral cells, mainly through PDT and prohibiting the growth and metastasis of deep cells through PDT as enhanced CT and GT. On the contrary, dual-modality nanomedicine lacking CT, GT, or PDT showed fast primary tumor growth, poor metastasis control, or both, respectively. This study reveals the spatiotemporally specific mechanism of CDTNs in treating metastatic TNBC and highlights the importance of combined therapy in treating TNBC. |
| WOS关键词 | ENHANCED PHOTODYNAMIC THERAPY ; UP-CONVERSION NANOPARTICLES ; E-CADHERIN ; TUMOR-MICROENVIRONMENT ; PROMOTES METASTASIS ; COLORECTAL-CANCER ; LUNG METASTASIS ; DRUG-RELEASE ; CHEMOTHERAPY ; HYPOXIA |
| 资助项目 | National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81671808] ; Youth Innovation Promotion Association of CAS[2017335] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000428972600073 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279864]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Pengcheng; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Jilin Univ, Changchun 130012, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Qingshuo,Meng, Jia,Ran, Wei,et al. Light-Activated Core-Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer[J]. ACS NANO,2018,12(3):2789-2802. |
| APA | Meng, Qingshuo.,Meng, Jia.,Ran, Wei.,Wang, Junyang.,Zhai, Yihui.,...&Li, Yaping.(2018).Light-Activated Core-Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer.ACS NANO,12(3),2789-2802. |
| MLA | Meng, Qingshuo,et al."Light-Activated Core-Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer".ACS NANO 12.3(2018):2789-2802. |
入库方式： OAI收割
来源：上海药物研究所
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