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(19 alpha H)-lupane and (9 beta H)-lanostane triterpenes from Euphorbia helioscopia trigger apoptosis of tumor cell

文献类型：期刊论文

作者Li, Jun1,2; Wang, Wen-qiong2; Song, Wei-bin2; Xuan, Li-jiang2
刊名FITOTERAPIA
出版日期2018-03
卷号125页码:24-32
ISSN号0367-326X
关键词Euphorbia helioscopia (19 alpha H)-lupane (9 beta H)-lanostane Apoptosis
DOI10.1016/j.fitote.2017.12.011
文献子类Article
英文摘要Chemical investigation of Euphorbia helioscopia resulted in the identification of seven new triterpenes named euphorbatrine A-G (1-7), including two (19 alpha H)-lupane (1-2) and three (9 beta H)-lanostane (4-6), which are very rare metabolites from plants. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallography and chemical methods. Compounds 5 and 6 triggered apoptosis of Hela(-/-) cell with EC50 values of 1.59 +/- 0.25 and 26.48 +/- 0.78 mu M, respectively.
WOS关键词DITERPENOIDS
资助项目State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Natural Science Foundation of China[81473111]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER SCIENCE BV
WOS记录号WOS:000425560500005
源URL[http://119.78.100.183/handle/2S10ELR8/279880]  
专题上海中药现代化研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
所领导
通讯作者Xuan, Li-jiang
作者单位1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Meteria Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Jun,Wang, Wen-qiong,Song, Wei-bin,et al. (19 alpha H)-lupane and (9 beta H)-lanostane triterpenes from Euphorbia helioscopia trigger apoptosis of tumor cell[J]. FITOTERAPIA,2018,125:24-32.
APA Li, Jun,Wang, Wen-qiong,Song, Wei-bin,&Xuan, Li-jiang.(2018).(19 alpha H)-lupane and (9 beta H)-lanostane triterpenes from Euphorbia helioscopia trigger apoptosis of tumor cell.FITOTERAPIA,125,24-32.
MLA Li, Jun,et al."(19 alpha H)-lupane and (9 beta H)-lanostane triterpenes from Euphorbia helioscopia trigger apoptosis of tumor cell".FITOTERAPIA 125(2018):24-32.

入库方式： OAI收割

来源：上海药物研究所

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