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AMPK regulates anaphase central spindle length by phosphorylation of KIF4A

文献类型：期刊论文

作者Li, Qian-Ru2; Yan, Xiu-Min3; Guo, Lin1; Li, Jia2; Zang, Yi2
刊名JOURNAL OF MOLECULAR CELL BIOLOGY
出版日期2018-02
卷号10期号:1页码:2-17
关键词AMPK phosphoregulation KIF4A mitosis central spindle length
ISSN号1674-2788
DOI10.1093/jmcb/mjx029
文献子类Article
英文摘要AMP-activated protein kinase (AMPK) is an energy sensor that couples the cellular energy state with basic biological processes. AMPK is thought to be linked with cell division although the underlying mechanisms remain largely unknown. Here, we show that AMPK functionally participates throughout cell division and that AMPK catalytic subunits, especially alpha 2, are sequentially associated with separate mitotic apparatus. Using quantitative phosphoproteomics analysis, we found that the strong direct substrate KIF4A is phosphorylated by AMPK at Ser801. Further analysis revealed that AMPK and Aurora B competitively phosphoregulates KIF4A during mitotic phase due to overlapping recognition motifs, resulting in the elaborate phosphoregulation for KIF4A-dependent central spindle length control. Given the intrinsic energy-sensing function of AMPK, our study links the KIF4A-dependent control of central spindle length with cellular glucose stress.
WOS关键词ACTIVATED PROTEIN-KINASE ; CHROMOSOME CONDENSATION ; MIDZONE FORMATION ; ENERGY SENSOR ; MITOTIC EXIT ; MICROTUBULE GENERATION ; CHROMOKINESIN KIF4A ; UPSTREAM KINASE ; HUMAN-CELLS ; HISTONE H3
资助项目National Natural Science Foundation of China[81673489] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM1705ZZ-02] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120161001] ; Science and Technology Commission of Shanghai Municipality[16430724100] ; Science and Technology Commission of Shanghai Municipality[14431902800]
WOS研究方向Cell Biology
语种英语
CSCD记录号CSCD:6201803
WOS记录号WOS:000428634600002
出版者OXFORD UNIV PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/279915]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药物安全性评价中心
通讯作者Guo, Lin; Li, Jia; Zang, Yi
作者单位1.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Li, Qian-Ru,Yan, Xiu-Min,Guo, Lin,et al. AMPK regulates anaphase central spindle length by phosphorylation of KIF4A[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2018,10(1):2-17.
APA Li, Qian-Ru,Yan, Xiu-Min,Guo, Lin,Li, Jia,&Zang, Yi.(2018).AMPK regulates anaphase central spindle length by phosphorylation of KIF4A.JOURNAL OF MOLECULAR CELL BIOLOGY,10(1),2-17.
MLA Li, Qian-Ru,et al."AMPK regulates anaphase central spindle length by phosphorylation of KIF4A".JOURNAL OF MOLECULAR CELL BIOLOGY 10.1(2018):2-17.

入库方式： OAI收割

来源：上海药物研究所

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