Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta
文献类型：期刊论文
| 作者 | Du Jing1; Ding Jie1; Mu Zhen-Qiang1; Guan Shu-Hong3 ; Cheng Chun-Ru1; Liu Xuan2; Guo De-An3
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2018-02 |
| 卷号 | 16期号:2页码:139-142 |
| 关键词 | Pinellia pedatisecta Alkaloids Structure identification Anti-tumor |
| ISSN号 | 2095-6975 |
| 文献子类 | Article |
| 英文摘要 | The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids (compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl) methyl)-9H-purin-6-amine (1),4-(2-(2, 5-dioxopyrrolidin-1-yl) ethyl) phenyl acetate (2), and N-(9-((5-methoxypyridin-2-yl) methyl)-9H-purin-6-yl) acetamide (3). These compounds were evaluated for their cytotoxicity against human cervical cancer HeLa cells. Compounds 1 and 3 significantly inhibited the proliferation of HeLa cells with IC50 values being 3.02 +/- 0.54 and 7.16 +/- 0.62 mu mol.L-1, respectively. |
| 资助项目 | National Natural Science Foundation of China[81373964] ; Introduction Program of Scientific Researcher of Sichuan University of Science Engineering[2016RCL07] ; Introduction Program of Scientific Researcher of Sichuan University of Science Engineering[2017RCL61] ; Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education[LYJ1302] ; Scientific Research Fund of the Sichuan Provincial Education Department[13ZB0133] ; Science and Technology Program Project of Sichuan[2015JY0024] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6171808 |
| WOS记录号 | WOS:000425298400008 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279926]  |
| 专题 | 成果转移转化处 上海中药现代化研究中心 |
| 通讯作者 | Cheng Chun-Ru; Liu Xuan |
| 作者单位 | 1.Sichuan Univ Sci & Engn, Sch Chem Engn, Sichuan Inst Higher Educ, Inst Pharmaceut Engn Technol & Applicat,Key Lab G, Zigong 643000, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Biomed Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Du Jing,Ding Jie,Mu Zhen-Qiang,et al. Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2018,16(2):139-142. |
| APA | Du Jing.,Ding Jie.,Mu Zhen-Qiang.,Guan Shu-Hong.,Cheng Chun-Ru.,...&Guo De-An.(2018).Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta.CHINESE JOURNAL OF NATURAL MEDICINES,16(2),139-142. |
| MLA | Du Jing,et al."Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta".CHINESE JOURNAL OF NATURAL MEDICINES 16.2(2018):139-142. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。