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Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes

文献类型：期刊论文

作者Qin, Jun-Jun3,4; Lin, Ze-Min5; Xu, Yan-Sheng5; Ren, Ji-Wen1; Zuo, Jian-Ping2; Zhao, Wei-Min3
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2018-02-01
卷号28期号:3页码:330-333
关键词Spiroorthoester group Pregnane glycosides Periploca chrysantha Immunosuppression
ISSN号0960-894X
DOI10.1016/j.bmcl.2017.12.045
文献子类Article
英文摘要Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides (1-4), named periplosides W-Y and 3-O-formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides (1-4) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A. (C) 2017 Elsevier Ltd. All rights reserved.
WOS关键词CHEMICAL-CONSTITUENTS ; ANTITUMOR FRACTION ; SEPIUM BGE ; IMMUNOSUPPRESSION ; ENCEPHALOMYELITIS ; CELLS ; MICE
资助项目Science and Technology Commission of Shanghai Municipality[15401901200] ; National Natural Science Foundation[81273399]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000424285600019
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/279930]  
专题药理学第一研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
天然药物化学研究室
通讯作者Zuo, Jian-Ping; Zhao, Wei-Min
作者单位1.Gansu Forestry Technol Coll, 58 Mapaoquan Rd, Tianshui 741020, Gansu, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China;
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
5.Shanghai Univ Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201210, Peoples R China;
推荐引用方式
GB/T 7714		 Qin, Jun-Jun,Lin, Ze-Min,Xu, Yan-Sheng,et al. Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(3):330-333.
APA Qin, Jun-Jun,Lin, Ze-Min,Xu, Yan-Sheng,Ren, Ji-Wen,Zuo, Jian-Ping,&Zhao, Wei-Min.(2018).Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(3),330-333.
MLA Qin, Jun-Jun,et al."Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.3(2018):330-333.

入库方式： OAI收割

来源：上海药物研究所

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