PTP1B inhibitory and cytotoxic C-24 epimers of Delta(28)-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes
文献类型:期刊论文
作者 | Feng, Mei-Tang1; Wang, Ting1; Liu, Ai-Hong3; Li, Jia2; Yao, Li-Gong2; Wang, Bin1; Guo, Yue-Wei2; Mao, Shui-Chun1 |
刊名 | PHYTOCHEMISTRY |
出版日期 | 2018-02 |
卷号 | 146页码:25-35 |
ISSN号 | 0031-9422 |
关键词 | Dictyopteris undulata Dictyopteris Dictyotaceae Stigmastane-type steroids Delta(28)-24-Hydroxy side chain Dictyopterisins A-J Modified Mosher's method X-ray diffraction PTP1B inhibitory activity Cytotoxicity |
DOI | 10.1016/j.phytochem.2017.11.013 |
文献子类 | Article |
英文摘要 | Ten stigmastane-type steroids bearing unusual Delta(28)-24-hydroxy side chains, dictyopterisins A-J, including three pairs of C-24 epimers, dictyopterisins B/C, FIG, and I/J, were isolated from the brown alga Dictyopteris undulata Holmes, together with two previously reported analogues, (24S)- and (24R)-saringosterol. Their structures were elucidated on the basis of extensive spectroscopic analysis, with their absolute configurations at the stereogenic center C-24 of the side chain being assigned by a direct comparison of H-1 NMR data with those of related known compounds. The absolute configurations of the steroidal nuclei of dictyopterisins A, B, and H were determined using the modified Mosher's method. The mixture of dictyopterisins D and E and dictyopterisin I exhibited promising PTP1B inhibitory activities with IC50 values of 1.88 and 3.47 mu M, respectively, comparable to the positive control oleanolic acid (IC50, 2.78 mu M). In addition, the mixture of dictyopterisins D and E and dictyopterisins F-J displayed significant cytotoxicities against the human cancer cell lines HL-60 (IC50 from 1.02 to 2.70 mu M) and A-549 (IC50 from 135 to 2.85 mu M). (C) 2017 Elsevier Ltd. All rights reserved. |
WOS关键词 | CAULERPA-RACEMOSA ; AERIAL PARTS ; SESQUITERPENE ; DIVARICATA ; YAMADA |
资助项目 | National Natural Science Foundation of China[21162016] ; National Natural Science Foundation of China[21362024] ; Natural Science Foundation of Jiangxi Province, China[20151BAB205082] ; Natural Science Foundation of Jiangxi Province, China[20161BAB205211] ; State Key Laboratory of Drug Research-SIMM[SIMM1601KF-10] |
WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000423895200004 |
源URL | [http://119.78.100.183/handle/2S10ELR8/279933] |
专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 药物安全性评价中心 |
通讯作者 | Mao, Shui-Chun |
作者单位 | 1.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Jiangxi, Peoples R China; |
推荐引用方式 GB/T 7714 | Feng, Mei-Tang,Wang, Ting,Liu, Ai-Hong,et al. PTP1B inhibitory and cytotoxic C-24 epimers of Delta(28)-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes[J]. PHYTOCHEMISTRY,2018,146:25-35. |
APA | Feng, Mei-Tang.,Wang, Ting.,Liu, Ai-Hong.,Li, Jia.,Yao, Li-Gong.,...&Mao, Shui-Chun.(2018).PTP1B inhibitory and cytotoxic C-24 epimers of Delta(28)-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes.PHYTOCHEMISTRY,146,25-35. |
MLA | Feng, Mei-Tang,et al."PTP1B inhibitory and cytotoxic C-24 epimers of Delta(28)-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes".PHYTOCHEMISTRY 146(2018):25-35. |
入库方式: OAI收割
来源:上海药物研究所
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