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Alzheimer's disease hypothesis and related therapies
文献类型：期刊论文
| 作者 | Du, Xiaoguang1; Wang, Xinyi1; Geng, Meiyu2
|
| 刊名 | TRANSLATIONAL NEURODEGENERATION
 |
| 出版日期 | 2018-01-30 |
| 卷号 | 7 |
| ISSN号 | 2047-9158 |
| 关键词 | Alzheimer's disease complicated disease anti-AD drugs Hypothesis about AD |
| DOI | 10.1186/s40035-018-0107-y |
| 文献子类 | Review |
| 英文摘要 | Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid beta (A beta) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies. |
| WOS关键词 | AMYLOID-BETA-PEPTIDE ; MILD COGNITIVE IMPAIRMENT ; VAGUS NERVE-STIMULATION ; BLOOD-BRAIN-BARRIER ; OXIDATIVE STRESS ; PRECURSOR PROTEIN ; GAMMA-SECRETASE ; TREM2 VARIANTS ; DOUBLE-BLIND ; CHOLINERGIC MODULATION |
| 资助项目 | "Personalized Medicines-Molecular Signature based Drug Discovery and Development", Strategic Priority Research program of Sciences[XDA12040101] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | BMC |
| WOS记录号 | WOS:000423707500001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279941]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Geng, Meiyu |
| 作者单位 | 1.Shanghai GreenValley Pharmaceut Co Ltd, 421 Newton Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Xiaoguang,Wang, Xinyi,Geng, Meiyu. Alzheimer's disease hypothesis and related therapies[J]. TRANSLATIONAL NEURODEGENERATION,2018,7. |
| APA | Du, Xiaoguang,Wang, Xinyi,&Geng, Meiyu.(2018).Alzheimer's disease hypothesis and related therapies.TRANSLATIONAL NEURODEGENERATION,7. |
| MLA | Du, Xiaoguang,et al."Alzheimer's disease hypothesis and related therapies".TRANSLATIONAL NEURODEGENERATION 7(2018). |
入库方式： OAI收割
来源：上海药物研究所
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