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Convenient preparation of pinometostat and related 5 '-deoxy-5 '-amino adenosine derivatives as well as their activity against DOT1L

文献类型：期刊论文

作者Liu, Tongchao1,2; Ren, Huanming2,4; Li, Cong3; Chen, Guohua4; Cheng, Maosheng1; Zhao, Dongmei1; Shen, Jingkang2,5; Li, Jia3,5; Zhou, Yubo3,5; Xiong, Bing2,5
刊名TETRAHEDRON LETTERS
出版日期2018-01-24
卷号59期号:4页码:415-417
关键词DOTI L inhibitor Pinometostat Amination 5 '-Deoxy-5 '-amino adenosine derivative Structure activity relationship
ISSN号0040-4039
DOI10.1016/j.tetlet.2017.12.064
文献子类Article
英文摘要From adenosine and 2'-C-Me adenosine, a 3-step route towards nucleoside DOT1L inhibitors, including pinometostat, EPZ5677, and FED1, was established. With useful structural-activity relationship information, the newly prepared 2'-C-Me adenosine derivatives contribute to the limited repertoire of ribose modified nucleoside DOT1L inhibitors. In general, this new synthetic method will facilitate not only the study of nucleoside DOT1L inhibitors, but also the synthetic and medicinal chemistry research of 5'-deoxy-5'-amino adenosine derivatives. (C) 2017 Elsevier Ltd. All rights reserved.
WOS关键词HISTONE METHYLTRANSFERASE DOT1L ; POTENT ; INHIBITORS ; LEUKEMIA
资助项目National Natural Science Foundation of China[81673309] ; National Science AMP[00000000] ; Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2014ZX09507-002] ; "Personalized Medicines - Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020310] ; program for Innovative Research Team of the Ministry of Education[00000000] ; program for Liaoning Innovative Research Team at Shenyang Pharmaceutical University[00000000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000424067200021
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/279949]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药物化学研究室
通讯作者Zhao, Dongmei; Zhou, Yubo; Xiong, Bing; Chen, Yue-Lei
作者单位1.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 103 Wenhua Lu, Shenyang 110016, Liaoning, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
3.Natl Ctr Drug Screening, 189 Guoshoujing Rd, Shanghai 201203, Peoples R China;
4.China Pharmaceut Univ, Sch Pharm, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China;
5.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Tongchao,Ren, Huanming,Li, Cong,et al. Convenient preparation of pinometostat and related 5 '-deoxy-5 '-amino adenosine derivatives as well as their activity against DOT1L[J]. TETRAHEDRON LETTERS,2018,59(4):415-417.
APA Liu, Tongchao.,Ren, Huanming.,Li, Cong.,Chen, Guohua.,Cheng, Maosheng.,...&Chen, Yue-Lei.(2018).Convenient preparation of pinometostat and related 5 '-deoxy-5 '-amino adenosine derivatives as well as their activity against DOT1L.TETRAHEDRON LETTERS,59(4),415-417.
MLA Liu, Tongchao,et al."Convenient preparation of pinometostat and related 5 '-deoxy-5 '-amino adenosine derivatives as well as their activity against DOT1L".TETRAHEDRON LETTERS 59.4(2018):415-417.

入库方式： OAI收割

来源：上海药物研究所

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