Confocal Raman micro-spectral evidence and physicochemical evaluation of triamterene salts
文献类型：期刊论文
| 作者 | Peng, Bo; Zhang, Zaiyong; Wang, Jian-Rong ; Li, Meiqi; Zhang, Qi; Mei, Xuefeng
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| 刊名 | The Analyst
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| 出版日期 | 2018-11-08 |
| ISSN号 | 1364-5528 |
| DOI | 10.1039/c8an01579a |
| 文献子类 | Article |
| 英文摘要 | Discrimination of active pharmaceutical ingredients (APIs) existing as neutral molecules or salts is essential and complicated. However, the discrimination of pharmaceutical salts by confocal Raman micro-spectroscopy remains relatively poorly understood. In this paper, four new salts of triamterene (Tri) cocrystallized with nicotinic acid (NA), benzoic acid (BA), p-toluenesulfonic acid (TA), or isonicotinic acid (INA) were prepared and characterized comprehensively by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), polarized light microscopy (PLM), and dynamic vapor sorption (DVS). Ionized pteridine is identified by marker peaks in the confocal Raman micro-spectra that are characteristic of C[double bond, length as m-dash]N. The single crystal structures of Tri-NA·H2O and Tri-TA further demonstrate that a proton transfers from the carboxylic group of NA or TA to the pyrimidine N1 atom of Tri and their salts formation take place. The intrinsic dissolution rate (IDR) and apparent equilibrium solubility of these four salts are improved compared to the pure Tri component, especially for Tri-BA. This study provides a valuable insight into pharmaceutical salt discrimination by vibrational spectroscopy and presents that the combination of Tri with an acid can be a possible and promising alternative formulation of Tri. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266263]  |
| 专题 | 药物质量控制与固体化学研究中心 药物安全性评价中心 |
| 通讯作者 | Peng, Bo; Zhang, Zaiyong; Wang, Jian-Rong; Li, Meiqi; Zhang, Qi; Mei, Xuefeng |
| 作者单位 | Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China |
| 推荐引用方式 GB/T 7714 | Peng, Bo,Zhang, Zaiyong,Wang, Jian-Rong,et al. Confocal Raman micro-spectral evidence and physicochemical evaluation of triamterene salts[J]. The Analyst,2018. |
| APA | Peng, Bo,Zhang, Zaiyong,Wang, Jian-Rong,Li, Meiqi,Zhang, Qi,&Mei, Xuefeng.(2018).Confocal Raman micro-spectral evidence and physicochemical evaluation of triamterene salts.The Analyst. |
| MLA | Peng, Bo,et al."Confocal Raman micro-spectral evidence and physicochemical evaluation of triamterene salts".The Analyst (2018). |
入库方式： OAI收割
来源：上海药物研究所
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