Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol
文献类型：期刊论文
| 作者 | Zha, Jun2,3; Zhang, Qi3; Li, Meiqi1,3; Wang, Jian-Rong3 ; Mei, Xuefeng3
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| 刊名 | Journal of pharmaceutical sciences
 |
| 出版日期 | 2018-11 |
| 卷号 | 107期号:11页码:2860-2868 |
| ISSN号 | 1520-6017 |
| DOI | 10.1016/j.xphs.2018.07.008 |
| 文献子类 | Article |
| 英文摘要 | Two polymorphs of celastrol were discovered and fully characterized by X-ray powder diffraction, thermogravimetry analysis, and differential scanning calorimetry. The single-crystal structures of form I and the isostructural solvate of form II were disclosed by single-crystal X-ray diffraction. The apparent solubility and wettability of both the crystalline forms were determined. It was found that surfactant can significantly improve the solubility of celastrol up to more than 10 times. Tween 80 and sodium dodecyl sulfate largely improved the wettability of the 2 crystals. Form I shows better wettability than form II in all the buffer solutions with polymers and surfactants. Compared with form II, form I exhibits higher solubility in carboxymethylcellulose and polyvinylpyrrolidone media but much lower solubility in tween 80 and sodium dodecyl sulfate solutions. An investigation of wettability and solubility mechanisms was fully explored, and a hypothesis was proposed to understand the abnormal solubility differences. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266289]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | 1.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China 2.Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215213, China; 3.Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | Zha, Jun,Zhang, Qi,Li, Meiqi,et al. Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol[J]. Journal of pharmaceutical sciences,2018,107(11):2860-2868. |
| APA | Zha, Jun,Zhang, Qi,Li, Meiqi,Wang, Jian-Rong,&Mei, Xuefeng.(2018).Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol.Journal of pharmaceutical sciences,107(11),2860-2868. |
| MLA | Zha, Jun,et al."Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol".Journal of pharmaceutical sciences 107.11(2018):2860-2868. |
入库方式： OAI收割
来源：上海药物研究所
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