RP-HPLC determination of irinotecan hydrochloride(CPT-11) and its related substances
文献类型：期刊论文
| 作者 | Qiao Shanbao1; Ji Min2; Xiang Lili2; Chen Dongying2
|
| 刊名 | Chinese Journal of Pharmaceutical Analysis
 |
| 出版日期 | 2013 |
| 卷号 | 33期号:3页码:439-442 |
| 关键词 | HPLC ion - pair irinotecan hydrochloride (CPT - 11) impurity analysis forced degradation quality control camptothecin derivatives |
| ISSN号 | 0254-1793 |
| 其他题名 | 反相离子对高效液相色谱法检查盐酸伊立替康(CPT-11)有关物质 |
| 文献子类 | Article |
| 英文摘要 | Objective: To optimize the testing method of irinotecan hydrochloride and its related substances by reversed - phase ion - pair high performance chromatography (RP - HPLC). Methods: The optimized separation was operated on a C_(18) column(150 mm * 4. 6 mm, 5 mum) with an isocratic mobile phase composed of methanol - 20 mmol·L~(-1) disodium hydrogen phosphate (containing 7. 7 mmol·L~(-1) octane sulfonate) (50: 50). The column temperature was set at 40 ℃ and the UV detection wavelength was 255 nm. Results: The RP - HPLC method significantly improved the retention behavior and separation of irinotecan hydrochloride and its related substances. The total operation time was no more than 10 min. Specificity was further assessed though the forced degradation tests. Conclusion: The optimized method is rapid and sensitive which is practical in accordance with the quality control requirement of testing the related substances in irinotecan hydrochloride. |
| 资助项目 | 盐城师范学院教授基金[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4797865 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267801]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 作者单位 | 1.School of Chemistry and Chemical Engineering, Yancheng Normal University, Yancheng, Jiangsu 224002, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Qiao Shanbao,Ji Min,Xiang Lili,et al. RP-HPLC determination of irinotecan hydrochloride(CPT-11) and its related substances[J]. Chinese Journal of Pharmaceutical Analysis,2013,33(3):439-442. |
| APA | Qiao Shanbao,Ji Min,Xiang Lili,&Chen Dongying.(2013).RP-HPLC determination of irinotecan hydrochloride(CPT-11) and its related substances.Chinese Journal of Pharmaceutical Analysis,33(3),439-442. |
| MLA | Qiao Shanbao,et al."RP-HPLC determination of irinotecan hydrochloride(CPT-11) and its related substances".Chinese Journal of Pharmaceutical Analysis 33.3(2013):439-442. |
入库方式： OAI收割
来源：上海药物研究所
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