Dopaminergic Alkaloids from Menispermum dauricum
文献类型：期刊论文
| 作者 | Yu BW(于丙午); Chen JY(陈建勇); He Y(和友); Jin GZ(金国章) ; Qin GW(秦国伟)
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| 刊名 | Chinese Journal of Natural Medicines
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:4页码:249-252 |
| 关键词 | Menispermum dauricum Meniscoside Effects on D_1 and D_2 receptors Alkaloid Meniscoside |
| ISSN号 | 1672-3651 |
| 其他题名 | 蝙蝠葛中的多巴胺能生物碱 |
| 文献子类 | Article |
| 英文摘要 | AIM:To study the bioactive components of the rhizoma of Menispermum dauricum.METHODS:Repeated column chromatography was used for the separation of the compounds and various spectroscopic techniques were applied for structural determination.RESULTS:Eight compounds,meniscoside(1),dauricoside(2),dauriporphine(3),menisporphine(4),bianfugecine(5),2,3-dihydromenisporphine(6),syringaresinol(7),and syringaresinol 4,4′-O-bis-glucoside(8)were obtained and identified.The effects on D_1 and D_2 receptors labeled with[~3H]were evaluated.CONCLUSION:Compound 1 was a new glucosidic benzylisoquinoline.Compounds 1-6 showed significant selective affinity to D_1 receptor,and the IC_(50)of 1 and 2 were 9.2 and 2.0mumol·L~(-1),respectively. |
| 资助项目 | National Natural Sciences Foundation of China[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4258480 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267873]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Yu BW,Chen JY,He Y,et al. Dopaminergic Alkaloids from Menispermum dauricum[J]. Chinese Journal of Natural Medicines,2011,9(4):249-252. |
| APA | 于丙午,陈建勇,和友,金国章,&秦国伟.(2011).Dopaminergic Alkaloids from Menispermum dauricum.Chinese Journal of Natural Medicines,9(4),249-252. |
| MLA | 于丙午,et al."Dopaminergic Alkaloids from Menispermum dauricum".Chinese Journal of Natural Medicines 9.4(2011):249-252. |
入库方式： OAI收割
来源：上海药物研究所
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