Interaction of 6-hydroxylycopodine with acetylcholinesterase
文献类型：期刊论文
| 作者 | Wang Yanli2; Li Yiming1; He Ying2; Tan Changheng3 ; Zhu Dayuan3; Du Weihong2
|
| 刊名 | Scientia Sinica Chimica
 |
| 出版日期 | 2010 |
| 卷号 | 40期号:9页码:1444-1450 |
| 关键词 | 6-hydroxylycopodine acetylcholinesterase interaction |
| ISSN号 | 1674-7224 |
| 其他题名 | 6-羟基石松碱与乙酰胆碱酯酶的相互作用 |
| 文献子类 | Article |
| 英文摘要 | Acetylcholinesterase inhibitors (AChEI) are mainly used in the treatment of Alzheimer's disease(AD).In order to investigate the inhibition of lycopodium alkaloids on acetylcholinesterase, the compound 6-hydroxylycopodine(HLD) was used as a potential candidate in the present work. The interaction of HLD with AChE was studied combining NMR, molecule docking, enzymatic activity determination, molecular dynamics simulation and binding free energy analysis. Experimental data reveal that HLD can inhibit AChE in a mixed type, and the HLD-AChE binding is mainly from the hydrogen bond and the Van der Waals interaction |
| 资助项目 | 国家科技重大专项"重大新药创制"基金[00000000] ; 上海市"东方学者"人才计划的资助[00000000] |
| WOS研究方向 | Chemistry (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4067817 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267927]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; 2.Department of Chemistry, Renmin University of China, Beijing 100872, China.; 3.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Wang Yanli,Li Yiming,He Ying,et al. Interaction of 6-hydroxylycopodine with acetylcholinesterase[J]. Scientia Sinica Chimica,2010,40(9):1444-1450. |
| APA | Wang Yanli,Li Yiming,He Ying,Tan Changheng,Zhu Dayuan,&Du Weihong.(2010).Interaction of 6-hydroxylycopodine with acetylcholinesterase.Scientia Sinica Chimica,40(9),1444-1450. |
| MLA | Wang Yanli,et al."Interaction of 6-hydroxylycopodine with acetylcholinesterase".Scientia Sinica Chimica 40.9(2010):1444-1450. |
入库方式： OAI收割
来源：上海药物研究所
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