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EFFECT OF PINELLIA EXTRACT ON PROLIFERATION OF CERVICAL CANCER CELL LINES AND ASSOCIATED MECHANISM

文献类型：期刊论文

作者Li Guiling2; Gui Suiqi2; Xia Qing3; Chen Songhua3; Ge Xirui3; Lin Ligen1; Ye Yang1
刊名Chinese Journal of Histochemistry and Cytochemistry
出版日期2010
卷号19期号:1页码:53-57
关键词Pinellia extract Cervical cancer CaSki cell line HeLa cell line Exfernal Signal-regulated xinase p-ERK
ISSN号1004-1850
其他题名掌叶半夏有效提取物对宫颈癌细胞株增殖的抑制作用
文献子类Article
英文摘要Objective To investigate the effects of Pinellia extract (PE) on cervical cancer cell lines CaSki and HeLa cultured in vitro, based on the previous research of Pinellia's effective treatment of cervical cancer. Methods Changes of ultrastructure were observed by electron microscopy. In-cell Western blot was used to estimate the relative protein amounts of phosphorylated ERK of CaSki and HeLa cells treated with different concentrations of PE for 15 minutes.Results PE inhibited the proliferation of CaSki and HeLa cells in a time- and dose-dependent manner. Electron microscopy revealed that the morphology and ultrastructure of CaSki and HeLa cells changed a lot. PE inhibited the phosphorylation of ERK in a dose-dependent manner.Conclusion PE can suppress proliferation of cervical cancer cells and induce changes in morphology and ultrastructure of CaSki and HeLa. Blocking of the MAPK/ERK signal transduction pathway by PE is involved in the mechanisms. This result will provide a certain experimental basis for the research of PE's antitumor effects.
资助项目上海市科委基金[00000000]
WOS研究方向Oncology (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:3810278
源URL[http://119.78.100.183/handle/2S10ELR8/267928]  
专题天然药物化学研究室
作者单位1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2.Department of Integrated Traditional Chinese and Western Medicine,Hospital of Obstetricsand Gynecology,Fudan University, Shanghai 200011, China.;
3.Cell Resources Center, Shanghai Institutes of Biological Sciences,CAS, Shanghai 200031, China.;
推荐引用方式
GB/T 7714		 Li Guiling,Gui Suiqi,Xia Qing,et al. EFFECT OF PINELLIA EXTRACT ON PROLIFERATION OF CERVICAL CANCER CELL LINES AND ASSOCIATED MECHANISM[J]. Chinese Journal of Histochemistry and Cytochemistry,2010,19(1):53-57.
APA Li Guiling.,Gui Suiqi.,Xia Qing.,Chen Songhua.,Ge Xirui.,...&Ye Yang.(2010).EFFECT OF PINELLIA EXTRACT ON PROLIFERATION OF CERVICAL CANCER CELL LINES AND ASSOCIATED MECHANISM.Chinese Journal of Histochemistry and Cytochemistry,19(1),53-57.
MLA Li Guiling,et al."EFFECT OF PINELLIA EXTRACT ON PROLIFERATION OF CERVICAL CANCER CELL LINES AND ASSOCIATED MECHANISM".Chinese Journal of Histochemistry and Cytochemistry 19.1(2010):53-57.

入库方式： OAI收割

来源：上海药物研究所

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