Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection
文献类型：期刊论文
| 作者 | PAN Feng1; CHEN Qing-hua1; BAO Yong-chu1; ZHU Da-yuan2; JIANG Shan-hao2 |
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2009 |
| 卷号 | 40期号:6页码:421-424 |
| 关键词 | huperzine A microsphere burst effect o/w emulsion in-liquid drying process o/o emulsion in-liquid drying process |
| ISSN号 | 1001-8255 |
| 其他题名 | 石杉碱甲注射用缓释微球制备方法的比较及其体内外评价 |
| 文献子类 | Article |
| 英文摘要 | The biodegradable sustained-release microspheres loaded with huperzine A for injection were prepared by o/w and o/o emulsion in-liquid drying process,respectively.The physicochemical properties of huperzine A-PLGA microspheres prepared by two methods were comparatively studied in terms of the morphology,particle size and the distribution,as well as the in vivo and in vitro drug release behavior.The results showed that the method of o/o emulsion in-liquid drying process had the advantage in preparing of injectable huperzine A microspheres. |
| 资助项目 | 上海市科蚕2002年重点科研项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3543312 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267977]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China.; 2.Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | PAN Feng,CHEN Qing-hua,BAO Yong-chu,et al. Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection[J]. Chinese Journal of Pharmaceuticals,2009,40(6):421-424. |
| APA | PAN Feng,CHEN Qing-hua,BAO Yong-chu,ZHU Da-yuan,&JIANG Shan-hao.(2009).Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection.Chinese Journal of Pharmaceuticals,40(6),421-424. |
| MLA | PAN Feng,et al."Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection".Chinese Journal of Pharmaceuticals 40.6(2009):421-424. |
入库方式： OAI收割
来源：上海药物研究所
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