Apoptosis induction effect of Pinellia extract fraction on cell lines of cervical cancer cultured in vitro
文献类型：期刊论文
| 作者 | LI Guiling1; GUI Suiqi1; CHEN Songhua3; GE Xiui3; LIN Ligen2; YE Yang2
|
| 刊名 | China Journal of Traditional Chinese Medicine and Pharmacy
 |
| 出版日期 | 2008 |
| 卷号 | 23期号:5页码:447-449 |
| 关键词 | Pinellia extract fraction Extract Apoptosis Cervical cancer HeLa and CaSki cell lines |
| ISSN号 | 1673-1727 |
| 其他题名 | 掌叶半夏提取物的有效部位对体外培养宫颈癌细胞的促凋亡作用 |
| 文献子类 | Article |
| 英文摘要 | Objective： To investigate the apoptosis induction effect of Pinellia extract fraction（PE） on two cell lines of cervical cancer cultured in vitro, in order to find a pure traditional Chinese reagent to treat cervical cancer effectively. Methods： PE was incubated in different concentrations with cervical cancer cell lines HeLa and CaSki. We tested the effects of PE on cell proliferation by MTT assay. The effects of PE on morphology, and cell cycle were studied by phase-contrast microscope and flowcytometry （FCM）. Results： PE could obviously inhibit the proliferation of HeLa and CaSki cells in a time and dose dependent manner. It could induce apoptosis of HeLa and CaSki. Conclusions： PE can suppress proliferation of cervical cancer cells and induce apoptosis. It may be a pure traditional Chinese reagent with non-side effects to prevent and treat cervical cancer effectively. |
| 资助项目 | 上海市科委医学引导项目基金资助（No.074119613）[00000000] |
| WOS研究方向 | Oncology ; General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3295723 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268033]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.Obstetrics and Gynecology Hospital Affiliated to Fudan University, Shanghai 200011, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 3.Cell Resources Center, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; |
| 推荐引用方式 GB/T 7714 | LI Guiling,GUI Suiqi,CHEN Songhua,et al. Apoptosis induction effect of Pinellia extract fraction on cell lines of cervical cancer cultured in vitro[J]. China Journal of Traditional Chinese Medicine and Pharmacy,2008,23(5):447-449. |
| APA | LI Guiling,GUI Suiqi,CHEN Songhua,GE Xiui,LIN Ligen,&YE Yang.(2008).Apoptosis induction effect of Pinellia extract fraction on cell lines of cervical cancer cultured in vitro.China Journal of Traditional Chinese Medicine and Pharmacy,23(5),447-449. |
| MLA | LI Guiling,et al."Apoptosis induction effect of Pinellia extract fraction on cell lines of cervical cancer cultured in vitro".China Journal of Traditional Chinese Medicine and Pharmacy 23.5(2008):447-449. |
入库方式： OAI收割
来源：上海药物研究所
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