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Initially Research in Acetylcholinesterase Inhibitory Activity of Endophytic Fungi g5 Isolated from Huperzia serrata

文献类型：期刊论文

作者CHENG Xi2; CHEN Jun2; ZHU DaYuan1
刊名Microbiology
出版日期2008
卷号35期号:11页码:1764-1768
关键词Acetylcholinesterase Huperzia serrata Endophytic fungi
ISSN号0253-2654
其他题名蛇足石杉内生真菌g5的乙酰胆碱酯酶抑制活性初步研究
文献子类Article
英文摘要It was about the initially research in the kinetics of inhibiting acetylcholinesterase（AChE）of endophytic fungi g5 which Isolated from Huperzia serrata.In addition,morphologic determination was done with this fungus.The effect of EtOH extraction from g5 fermentative product on the inhibiting AChE was detected by coloration of DTNB method,and this fungus was determinated by slide culture.The result is that g5 belongs to Penicillium rugulosum.According to Initially analysis of enzyme kinetics,it was showed that g5 was admixed competitive reversible inhibitory type,and the inhibit-constant KI against free E and KIS against comoles compound of ES is 0.0789 mL and 1.1352 mL,respectively.The metabolic product of g5 can be developed as potential drugs which is not only conspicuous but also reversible inhibiting AChE in vitro.
资助项目中国科学院知识创新工程重大项目子课题（No.KSCX1-SW-11-6）[00000000]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:3470366
源URL[http://119.78.100.183/handle/2S10ELR8/268078]  
专题天然药物化学研究室
作者单位1.State Key Laboratory of Drug Research,Shanghai Institute of Medicines,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences, Shanghai 201023, China.
2.College of Pharmacy,Jiangsu University, Zhenjiang, Jiangsu 212013, China.;
推荐引用方式
GB/T 7714		 CHENG Xi,CHEN Jun,ZHU DaYuan. Initially Research in Acetylcholinesterase Inhibitory Activity of Endophytic Fungi g5 Isolated from Huperzia serrata[J]. Microbiology,2008,35(11):1764-1768.
APA CHENG Xi,CHEN Jun,&ZHU DaYuan.(2008).Initially Research in Acetylcholinesterase Inhibitory Activity of Endophytic Fungi g5 Isolated from Huperzia serrata.Microbiology,35(11),1764-1768.
MLA CHENG Xi,et al."Initially Research in Acetylcholinesterase Inhibitory Activity of Endophytic Fungi g5 Isolated from Huperzia serrata".Microbiology 35.11(2008):1764-1768.

入库方式： OAI收割

来源：上海药物研究所

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