Ethyl acetate extracted from Shiitake Mushroom induced apoptosis in a breast cancer cell line-MCF-7
文献类型：期刊论文
| 作者 | LI Qinglin1; LUO Hongfeng2 ; FANG Nianbai
|
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2006 |
| 卷号 | 22期号:8页码:1001-1004 |
| 关键词 | MCF-7 ethyl acetate extract of shiitake mushroom MCF-7 human breast cancer cell lines apoptosis cell cycle |
| ISSN号 | 1001-1978 |
| 其他题名 | 椎茸的乙酸乙脂提取物诱导人乳腺癌MCF-7细胞凋亡的作用 |
| 文献子类 | Article |
| 英文摘要 | Aim This study was to examine the effect of ethyl acetate extract of shiitake mushroom on a human breast cancer line-MCF-7 cell in vitro. Method Cell cytotoxicity was examined using MTT method, Cell apoptosis was examined by AnnexinV-FITC/PI staining, Cell cycle analysis was determined by flow cy-tometry. Western blot analysis was used to determine Cyclin Dt ,Cdk4,Bax and p21WAEl/CIPl protein expression. Results Concentration-dependent cytotoxic effects of the extract were observed in MCF-7 human breast cancer cell lines. Pro-apoptotic proteins ( Bax, p21 WAE1/C1P1) were up-regulated while proteins involved in cell cycle (Cyclin D, and Cdk4)were down-regulated. Conclusion This study suggests that the anti-breast cancer activities might result from increased apoptosis and growth arrest. |
| WOS研究方向 | General & Internal Medicine ; Oncology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2432192 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268213]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.Anhui College of Traditional Chinese Medicine, Anhui key Ijaboralory of Modernized Chinese Material Medica, Hefei, Anhui 230038, China.; 2.Shanghai Institute of Material Medina, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LI Qinglin,LUO Hongfeng,FANG Nianbai. Ethyl acetate extracted from Shiitake Mushroom induced apoptosis in a breast cancer cell line-MCF-7[J]. Chinese Pharmacological Bulletin,2006,22(8):1001-1004. |
| APA | LI Qinglin,LUO Hongfeng,&FANG Nianbai.(2006).Ethyl acetate extracted from Shiitake Mushroom induced apoptosis in a breast cancer cell line-MCF-7.Chinese Pharmacological Bulletin,22(8),1001-1004. |
| MLA | LI Qinglin,et al."Ethyl acetate extracted from Shiitake Mushroom induced apoptosis in a breast cancer cell line-MCF-7".Chinese Pharmacological Bulletin 22.8(2006):1001-1004. |
入库方式： OAI收割
来源：上海药物研究所
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