Inhibition of xathine oxidase by renierol extracted from South China Sea sponge
文献类型：期刊论文
| 作者 | Shang Yanjun2; Guo Yuewei1 ; Huang Caiguo2; Jia Rui1; Xu Qiangzhi2; Wei Shanjian2; Jiao Binghua2; Zhang Jianrong1
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| 刊名 | Academic Journal of Second Military Medical University
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:1页码:25-27 |
| 关键词 | renierol renierol sponge marine biology xanthine oxidase hyperuricemia |
| ISSN号 | 0258-879X |
| 其他题名 | 中国南海海绵提取物renierol对黄嘌呤氧化酶的抑制作用 |
| 文献子类 | Article |
| 英文摘要 | Objective：To study the inhibition of xanthine oxidase by renierol extracted from South China Sea sponge and study the influence of renierol on hyperuricemia in mice. Methods： After extracted from South China Sea sponge, renierol （20, 40, 60 mug/ml） was added to a system containing xanthine oxidase （0. 1 mu/ml） and xanthine （50 mumol/ml）; allopurinol （1 mug/ml）was also addded to the system as positive control. The5 min-fomation of superoxide anions was used to determine the activity of xanthine oxidase （Nitro Blue Btetrazolium reduction）. Renierol （20, 40, 60 mug/ml） was added to 25℃ pre heated pyrogallol autoxidation to observe its eliminating effect on free radicals through determining the absorbance rate at 420 nm wavelength. Potassium oxonate, a uricaseinhibitor, was used to induce hyperuricemia in mice and the mice were then treated withoral renierol （10, 20, 30 mg·kg^-1） orallopurinol （2 mg/kg） as positive control. The decrease of serum uric acid induced byrenierol was determined by automatic biochemical analyzer. Results： Renierol was demonstrated to be a competitive inhibitor of xanthine oxidase in vitru, with its IC〉 value being 1.36mug·ml^-1. It also decreased uric acid in vivo. Conclusion： Renierol can decrease serum uric acid through inhibiting the xanthine oxidase . |
| 资助项目 | 上海市中药现代化专项基金[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2297630 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268266]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Shanghai 201203, China. 2.Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.; |
| 推荐引用方式 GB/T 7714 | Shang Yanjun,Guo Yuewei,Huang Caiguo,et al. Inhibition of xathine oxidase by renierol extracted from South China Sea sponge[J]. Academic Journal of Second Military Medical University,2006,27(1):25-27. |
| APA | Shang Yanjun.,Guo Yuewei.,Huang Caiguo.,Jia Rui.,Xu Qiangzhi.,...&Zhang Jianrong.(2006).Inhibition of xathine oxidase by renierol extracted from South China Sea sponge.Academic Journal of Second Military Medical University,27(1),25-27. |
| MLA | Shang Yanjun,et al."Inhibition of xathine oxidase by renierol extracted from South China Sea sponge".Academic Journal of Second Military Medical University 27.1(2006):25-27. |
入库方式： OAI收割
来源：上海药物研究所
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