Total salvianolic acid inhibiting renal interstitial fibrosis in rats
文献类型：期刊论文
| 作者 | Shang Yanjun3; Huang Caiguo3; Jiang Shanhao1; Zhu Dayuan1; Wei Shanjian3; Jiao Binghua3; Li Kainan4; Zhang Jianrong2 |
| 刊名 | Academic Journal of Second Military Medical University
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:12页码:1295-1298 |
| 关键词 | total salvianolic acid renal interstitial fibrosis transforming growth factor-beta_1 |
| ISSN号 | 0258-879X |
| 其他题名 | 丹参总酚酸抑制大鼠肾间质纤维化的初步观察 |
| 文献子类 | Article |
| 英文摘要 | Objective:To study the influence of total salvianolic acid(TSA) on the renal interstitial fibrosis caused by unilateral ureteral obstruction (UUO) in rats. Methods, Forty healthy Sprague-Dawley rats were randomly divided into 4 groups: the UUO group, sham-operation group, angiotensin-converting enzyme inhibitor ( ACEI )-treated group (positive control), and TSA-treated group. The rats in UUO group and sham-operation group received gastric gavage with normal saline for 8 days before operation; rats in ACEI-treated group and TSA-treated group received ACEI (6 mg/kg by daily gastric gavage for 8 days) and TSA (20 mg/kg by daily gastric gavage for 8 days), respectively. Ail rats were killed 7 days after operation and the expression of transforming growth factor-beta_1(TGF-beta_1) was detected by immunohistochemical method. The dynamic histological changes of renal interstitial tissues were observed by H-E and Masson staining. Results, TGF-beta_1 expression in TSA-treated (1. 38 0. 26) and ACEI-treated (1.38 + 0.26) groups was significantly lower than that in UUO group(P<0. 05). TSA obviously reduced TGF-beta_1 expression and collagen deposition in the renal interstitial tissues and improved the renal pathological changes in UUO rats. Conclusion TSA can evidently inhibit UUO-induced renal interstitial fibrosis in rats, which might be related with the down regulation of TGF-beta_1 expression. |
| 资助项目 | 国家自然科学基金[00000000] |
| WOS研究方向 | Surgery (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2639533 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268268]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.; 2.Department of Experimental Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. 3.Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.; 4.Department of Pathology, College of Basic Medical Sciences, Forth Military Medical University, Xi'an, Shaanxi 710033, China.; |
| 推荐引用方式 GB/T 7714 | Shang Yanjun,Huang Caiguo,Jiang Shanhao,et al. Total salvianolic acid inhibiting renal interstitial fibrosis in rats[J]. Academic Journal of Second Military Medical University,2006,27(12):1295-1298. |
| APA | Shang Yanjun.,Huang Caiguo.,Jiang Shanhao.,Zhu Dayuan.,Wei Shanjian.,...&Zhang Jianrong.(2006).Total salvianolic acid inhibiting renal interstitial fibrosis in rats.Academic Journal of Second Military Medical University,27(12),1295-1298. |
| MLA | Shang Yanjun,et al."Total salvianolic acid inhibiting renal interstitial fibrosis in rats".Academic Journal of Second Military Medical University 27.12(2006):1295-1298. |
入库方式： OAI收割
来源：上海药物研究所
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