Quantitative determination of limonin in traditional Chinese medicine by LC-MS/MS
文献类型：期刊论文
| 作者 | Liu Gangyi2; Wang Guoquan3; Zhang Hui2; Yu Chen2; Ji Shen; Zhu Dayuan1 |
| 刊名 | Chinese Traditional Patent Medicine
 |
| 出版日期 | 2003 |
| 卷号 | 25期号:2页码:144-146 |
| 关键词 | LC-MS/MS limonin fructus evodiae LC-MS/MS |
| ISSN号 | 1001-1528 |
| 其他题名 | 中草药及制剂中吴茱萸内酯的LC-MS/MS测定方法 |
| 文献子类 | Article |
| 英文摘要 | Objective: To develop a simple LC-MS/MS method for the measurement of limonin in fructus evodiae, cortex phellodendri, cortex dictamni and its preparation. Methods: Separation was obtained by using a discovery C_(18) column (150mm*2.1mm), The mobile phase: A: water-0.1% HAc; B: acetonitrile-0.1%HAc; The elution program was gradient and the flow rate was 0.2mL·min~(-1). The mass detector was set MSI(IS)=187.0 and MS2(Limonin)=471.0 by multiple reaction monitor (MRM) respectively. The sample was added psoralen (IS), then extracted with methanol-chloroform (1:3). Results: Limonin was linear from 25 to 1000ng·mL~(-1)(r=0.9996), The regression equation was C=3.124As/Ai-1.935*10~(-3). The average recovery was 100.2%. Conclusion: This method is simple, quick, sensitive and exclusive. |
| 资助项目 | 上海市徐汇卫生局科研基金[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1471656 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268443]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, China Academy opf Sciences, 200031. 2.Xuhui District Central Hospital, Shanghai 200031, China.; 3.Shanghai Centre for Disease Control, Shanghai 200336, China.; |
| 推荐引用方式 GB/T 7714 | Liu Gangyi,Wang Guoquan,Zhang Hui,et al. Quantitative determination of limonin in traditional Chinese medicine by LC-MS/MS[J]. Chinese Traditional Patent Medicine,2003,25(2):144-146. |
| APA | Liu Gangyi,Wang Guoquan,Zhang Hui,Yu Chen,Ji Shen,&Zhu Dayuan.(2003).Quantitative determination of limonin in traditional Chinese medicine by LC-MS/MS.Chinese Traditional Patent Medicine,25(2),144-146. |
| MLA | Liu Gangyi,et al."Quantitative determination of limonin in traditional Chinese medicine by LC-MS/MS".Chinese Traditional Patent Medicine 25.2(2003):144-146. |
入库方式： OAI收割
来源：上海药物研究所
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