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The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island

文献类型：期刊论文

作者Li Songwei8; Yao Ligong4; Liang Linfu7; Guo Yuewei1
刊名Chinese Journal of Marine Drugs
出版日期2018
卷号37期号:4页码:1-6
ISSN号1002-3461
关键词soft coral steroids cytotoxicity
其他题名西瑁岛软珊瑚Sinulariasp.的化学成分和生物活性研究
文献子类Article
英文摘要Objective To study the chemical constituents and bioactivities of soft coral sinulariasp.collected from Ximao Island in South China Sea.Methods The isolation and purification of these compounds were performed by TLC,silica gel,Sephadex LH-20 column chromatography and semi-preparative HPLC.Their structures were characterized by analysis of NMR and MS data and comparison with the data reported in literatures.The cytotoxicity of these compoundsagainst A549 and HL-60 cell lines hasbeen tested by using Cell Counting Kit-8(CCK-8)method.Results Ten known steroids were isolated from the soft coral sinulariasp.and their structures were identified as pregna-5,20-dien-3beta-O-acetate( 1),pregna-20-en-3-one(2),pregna-1,20-dien-3-one(3),pregna-1,4,20-trien-3-one(4),pregna- 20-en-3beta-ol(5),pregna-5,20-dien-3beta-ol(6),pregna-1,4-dien-3-one-20alpha-O-acetate(7),alpha-galactopyranoside- 3beta-pregna-5,20-dien-3-yl-6-deoxy(8),(22E,24R)- ergosta-7,22-dien-3beta,5alpha,6beta-triol(9)and (20S)- 20-hydroxy cholost-1,4-dien-3,16-dione(10).Conclusion Though compounds 1~10 didn'texhibit potent cytotoxicity against A549 cell lines,compounds 4 and 7 showed moderate cytotoxicity against HL-60 cell lines with IC_(50) values of 1.61 and 3.26mumol/L,respectively.
资助项目国家自然科学基金项目[00000000] ; 国家自然科学基金山东联合基金项目[00000000] ; 上海市科委基金项目[00000000] ; 新药研究国家重点实验室项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:6308104
源URL[http://119.78.100.183/handle/2S10ELR8/269158]  
专题天然药物化学研究室
通讯作者Guo Yuewei
作者单位1.Shanghai Institute of MateriaMedica, Chinese Academy of Sciences;
2.Nanchang;
3.;
4.Shanghai Institute of MateriaMedica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai 201203, China.;
5.Shanghai
6.State Key Laboratory of Drug Research;
7.College of Materials Science and Engineering,Central South University of Forestry and Technology, Changsha, Hunan 410004, China.;
8.School of Pharmacy,Nanchang University;
9.Chinese Academy of Sciences,;
推荐引用方式
GB/T 7714		 Li Songwei,Yao Ligong,Liang Linfu,et al. The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island[J]. Chinese Journal of Marine Drugs,2018,37(4):1-6.
APA Li Songwei,Yao Ligong,Liang Linfu,&Guo Yuewei.(2018).The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island.Chinese Journal of Marine Drugs,37(4),1-6.
MLA Li Songwei,et al."The study on the chemical constituents and bioactivities of soft coral Sinulariasp.from Ximao Island".Chinese Journal of Marine Drugs 37.4(2018):1-6.

入库方式： OAI收割

来源：上海药物研究所

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