Studies on methyl xestopongoate analogues:design,synthesis and antitumor activities
文献类型：期刊论文
| 作者 | Sun Dongyu3; Gong Jingxu5; Li Xuwen5 ; Han Guanying3; Guo Yuewei5
|
| 刊名 | Journal of China Pharmaceutical University
 |
| 出版日期 | 2018 |
| 卷号 | 49期号:4页码:413-421 |
| ISSN号 | 1000-5048 |
| 关键词 | Methyl Xestospongoate Methyl Xestospongoate polyacethlene analogues synthesis antitumor activity |
| 其他题名 | Methyl Xestospongoate类似物的设计、合成和抗肿瘤活性 |
| 文献子类 | Article |
| 英文摘要 | Fifty-two methyl xestospongoate analogues were designed,synthesized and evaluated for the antiproliferative activity.Starting from alkynyl methyl ester and diyne,methyl xestospongoate analogues 4(a-m)-7(a-m) were synthesized by Cadiot-Chodkiewitz coupling and Sonogashira coupling reactions. Their structures were identified by ~1H NMR,~(13)C NMR and HREI-MS. The cytotoxic inhibiton activities in vitro of some compounds were evaluated against human cancer cells A549 and P-388 by a CCK-8 method.Among them,compound 6k exhibited potent cell growth inhibitory activity against A549 and P-388 cancer cells,with IC_(50) values of 9.36 and 9.62 mumol/L,respectively. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6322722 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269160]  |
| 专题 | 天然药物化学研究室 |
| 通讯作者 | Guo Yuewei |
| 作者单位 | 1.; 2.Jinzhou; 3.School of Pharmacy,Jinzhou Medical University; 4.Chinese Academy of Sciences,; 5.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Sun Dongyu,Gong Jingxu,Li Xuwen,et al. Studies on methyl xestopongoate analogues:design,synthesis and antitumor activities[J]. Journal of China Pharmaceutical University,2018,49(4):413-421. |
| APA | Sun Dongyu,Gong Jingxu,Li Xuwen,Han Guanying,&Guo Yuewei.(2018).Studies on methyl xestopongoate analogues:design,synthesis and antitumor activities.Journal of China Pharmaceutical University,49(4),413-421. |
| MLA | Sun Dongyu,et al."Studies on methyl xestopongoate analogues:design,synthesis and antitumor activities".Journal of China Pharmaceutical University 49.4(2018):413-421. |
入库方式： OAI收割
来源：上海药物研究所
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