Studies on the chemical constitutions of sponge Mycale biacuta from the North China Sea
文献类型：期刊论文
| 作者 | Wang Jiahui1; Wang Chunhua3; Yao Ligong1; Guo Yuewei1 ; Liu Haili2
|
| 刊名 | Chinese Journal of Marine Drugs
 |
| 出版日期 | 2017 |
| 卷号 | 36期号:6页码:11-17 |
| 关键词 | Mycale biacuta indole alkaloids aromatics triterpene |
| ISSN号 | 1002-3461 |
| 其他题名 | 广西北海涠洲岛双尖山海绵Mycale biacuta的化学成分研究 |
| 文献子类 | Article |
| 英文摘要 | Objective To study the chemical constitutions of sponge Mycale biacuta. Methods The compounds were isolated and purified by repeated thin layer chromatography, silica gel column, Sephadex LH-20 column chromatography. The chemical structures were elucidated on the basis of extensive spectroscopic analysis, including NMR and MS, and by comparison with the data of literature. Results Sixteen known compounds were isolated from sponge Mycale biacuta, including a triterpene, squalene (1), six aromatics, 2,6-di-tert-butyl-4-methylphenol (2), (2,4-dichlorophenyl)-2,4-dichlorobenzoate (3), p-hydroxybenzaldehyde (4), p-hydroxybenzoylcarbinol (5), phenylacetic acid (6),E-1-(4-hydroxyphenyl)-buten-3-one (7), five indolealkaloids,1,3-dihydro-2H-indole-2-one (8), 3-indolecarboxylic acid (9), indole-5-carboxaldehyde (10), 3-(propan-2-yliden) indolin-2-one (11),3',3'-dimethylspiro[indolin-3,2'-oxiran]-2-one (12), and four nucleosides, adenosine (13), deoxyadenosine (14), 2'-deoxyuridine (15), and thymidine (16). Conclusion Compounds 1~16 were isolated from this species for the first time. Compounds 11 and 12 were new natural products. |
| 资助项目 | 国家自然科学基金项目[00000000] ; 上海市科委基金项目[00000000] ; 新药研究国家重点实验室项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6129100 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269189]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Key Laboratory of Synthetic Biology,Chinese Academy of Sciences, Shanghai 201203, China. 3.School of Pharmcy, Binzhou Medical University, Yantai, Shandong 264003, China.; |
| 推荐引用方式 GB/T 7714 | Wang Jiahui,Wang Chunhua,Yao Ligong,et al. Studies on the chemical constitutions of sponge Mycale biacuta from the North China Sea[J]. Chinese Journal of Marine Drugs,2017,36(6):11-17. |
| APA | Wang Jiahui,Wang Chunhua,Yao Ligong,Guo Yuewei,&Liu Haili.(2017).Studies on the chemical constitutions of sponge Mycale biacuta from the North China Sea.Chinese Journal of Marine Drugs,36(6),11-17. |
| MLA | Wang Jiahui,et al."Studies on the chemical constitutions of sponge Mycale biacuta from the North China Sea".Chinese Journal of Marine Drugs 36.6(2017):11-17. |
入库方式： OAI收割
来源：上海药物研究所
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