中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 天然药物化学研究室
Terpenes from South China Sea soft coral Sarcophyton trocheliophrum

文献类型：期刊论文

作者Liang Linfu2; Guo Jiawei3; Fan Teng3; Yao Ligong1; Guo Yuewei1
刊名Chinese Traditional and Herbal Drugs
出版日期2016
卷号47期号:24页码:4331-4335
关键词deacetylemblide Sarcophyton trocheliophrum diterpene sesquiterpene deacetylemblide cembrene A protein tyrosine phosphatase 1B inhibitory activity
ISSN号0253-2670
其他题名中国南海圆盘肉芝软珊瑚萜类成分研究
文献子类Article
英文摘要Objective To investigate the terpenes of the South China Sea soft coral Sarcophyton trocheliophrum. Methods Subjected to ~1H-NMR-guided fractionation, the chemical constituents were isolated and purified using column chromatographies on silica gel, Sephadex LH-20, and high performance liquid chromatography (HPLC). Their structures were determined through the analysis of spectroscopic data. Results Eight diterpenes and one sesquiterpene were isolated from the ethyl ether soluble part of acetone extract of S. trocheliophrum and their structures were identified as cembrene A (1), (E,E,E)-7,8-epoxy-1-isopropyl-4,8,12- trimethylcyclotetradeca-l,3,11-triene (2), sarcophytonolide A (3), deacetylemblide (4), 4Z,12Z,14E-sarcophytolide (5), sarcrassin D (6), emblide (7), (4Z,8S,9R,12E,14E)-9-hydroxy-1-isopropyl-8,12-dimethyloxabicyclo [9.3.2]-hexadeca-4,12,14-trien-18-one (8), and beta-elemene (9), respectively. Conclusion Compound 4 is found to be a new natural product, and its ~(13)C-NMR data are recorded for the first time. Moreover, this is the first report that compounds 1, 3, 5, and 8 are obtained from the title soft coral. In bioassay, compound 5 exhibits the moderate human protein tyrosine phosphatase 1B (PTP1B) inhibitory activity (IC_(50) = 15.4 mumol/L).
资助项目国家自然科学基金资助项目[00000000] ; 上海市科学技术委员会科研计划项目[00000000] ; 湖南省自然科学基金资助项目[00000000] ; 中国科学院国家新药研究重点实验室项目[00000000] ; 中国科学院药物创新研究院自主部署科研项目[00000000] ; 中国博士后科学基金资助项目[00000000]
WOS研究方向General & Internal Medicine (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5887197
源URL[http://119.78.100.183/handle/2S10ELR8/269221]  
专题天然药物化学研究室
通讯作者Guo Yuewei
作者单位1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2.College of Material Science and Engineering, Central South University of Forestry and Technology, State Key Laboratory of Drug Research, Changsha, Hunan 410004, China.;
3.College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China.;
推荐引用方式
GB/T 7714		 Liang Linfu,Guo Jiawei,Fan Teng,et al. Terpenes from South China Sea soft coral Sarcophyton trocheliophrum[J]. Chinese Traditional and Herbal Drugs,2016,47(24):4331-4335.
APA Liang Linfu,Guo Jiawei,Fan Teng,Yao Ligong,&Guo Yuewei.(2016).Terpenes from South China Sea soft coral Sarcophyton trocheliophrum.Chinese Traditional and Herbal Drugs,47(24),4331-4335.
MLA Liang Linfu,et al."Terpenes from South China Sea soft coral Sarcophyton trocheliophrum".Chinese Traditional and Herbal Drugs 47.24(2016):4331-4335.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。