Study on the chemical constituents and antimicrobial activities of sesquiterpenes from the red algaLaurencia okamurai Yamada
文献类型：期刊论文
| 作者 | Tang Xuanliang1; Yu Xiaoqing1; Zhang Yi1; Liu Aihong2; Yao Ligong3; Guo Yuewei3 ; Wang Bin1; Feng Lihua1; Mao Shuichun1
|
| 刊名 | Chinese Journal of Marine Drugs
 |
| 出版日期 | 2015 |
| 卷号 | 34期号:6页码:12-22 |
| 关键词 | Laurencia okamurai chemical constituents sesquiterpenes antifungal activity antibacterial activity |
| ISSN号 | 1002-3461 |
| 其他题名 | 冈村凹顶藻的倍半萜类化学成分及抗菌活性研究 |
| 文献子类 | Article |
| 英文摘要 | Objective To isolate and identify sesquiterpenes of the red algaLaurencia okamurai Yamada and to evaluate their antimicrobial activities.Methods Compounds were isolated and purified by means of various chromatographic techniques including silica gel and Sephadex LH-20 column chromatography and reverse phase HPLC,while their structures were elucidated on the basis of spectroscopic analysis. The in vitro antifungal activity of six sesquiterpenes against four fungi(Cryptococcus neoformans, Candida glabrata,Trichophyton rubrum,and Aspergillus fumigatus)and antibacterial activity of all the isolates against two bacteria(Staphylococcus aureus and Pseudomonas aeruginosa)were evaluated using broth micro-dilution method.Results Seventeen known sesquiterpenes were isolated and identified as aplysinol(1),laureperoxide(2),aplysinal(3),alpha-isobromocuparene(4),alpha-isocuparenol(5),cuparene- type ether (6),laur-11-en-10-ol (7),laurinterol (8),laurinterol acetate (9),debromolaurinterol(10),isolaurinterol(11),isolaurinterol acetate(12),johnstonol(13),pacifenol(14),10- bromo-alpha-chamigrene(15),10-bromo-beta-chamigrene(16),and 4,10-dibromo-3-chloro-9-hydroxy-alpha-chamigrene(17),respectively.All of the isolated sesquiterpenes were evaluated for antimicrobial activities. Conclusion Compounds 5 and 7 were isolated for the first time fromLaurencia okamurai.The full ~1 H and ~(13)C NMR data were unambiguously assigned by 1Dand 2DNMR(~1 H~1 H COSY,HMQC,HMBC, and ROESY)experiments.Inin vitro antifungal bioassays,compounds 5 and13 exhibited potent inhibitory activity against the fungus Candida glabrata with MIC_(80) values of 1 and 4mug/mL,respectively, when compared to the positive controls,amphotericin B(MIC_(80)=2mug/mL)and fluconazole (MIC_(80) =1mug/mL),while compounds 2,8,and 9 showed moderate inhibitory activity against the fungus Cryptococcus neoformans.In addition,compounds 2,8-10,15,and 17 displayed different levels of antibacterial activity against the bacteriumStaphylococcus aureus.Among them,compounds 8 and 9 exhibited potent antibacterial activity with MIC_(80) values of 2.3 and 10.5mug/mL,respectively. |
| 资助项目 | 国家自然科学基金项目[00000000] ; 江西省青年科学家培养对象计划[00000000] ; 江西省自然科学基金[00000000] ; 江西省教育厅课题[00000000] ; 教育部留学回国人员科研启动基金资助[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5585910 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269262]  |
| 专题 | 天然药物化学研究室 |
| 作者单位 | 1.School of Pharmacy,Nanchang University, Nanchang, Jiangxi 330006, China.; 2.Center of Analysis and Testing,Nanchang University, Nanchang, Jiangxi 330047, China.; 3.State key laboratory of Drug Research,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Tang Xuanliang,Yu Xiaoqing,Zhang Yi,et al. Study on the chemical constituents and antimicrobial activities of sesquiterpenes from the red algaLaurencia okamurai Yamada[J]. Chinese Journal of Marine Drugs,2015,34(6):12-22. |
| APA | Tang Xuanliang.,Yu Xiaoqing.,Zhang Yi.,Liu Aihong.,Yao Ligong.,...&Mao Shuichun.(2015).Study on the chemical constituents and antimicrobial activities of sesquiterpenes from the red algaLaurencia okamurai Yamada.Chinese Journal of Marine Drugs,34(6),12-22. |
| MLA | Tang Xuanliang,et al."Study on the chemical constituents and antimicrobial activities of sesquiterpenes from the red algaLaurencia okamurai Yamada".Chinese Journal of Marine Drugs 34.6(2015):12-22. |
入库方式： OAI收割
来源：上海药物研究所
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