Polymorph transformation of solid drugs
文献类型：期刊论文
| 作者 | Zhang Qi; Mei Xuefeng
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2015 |
| 卷号 | 50期号:5页码:521-527 |
| 关键词 | drug stability polymorphism transformation |
| ISSN号 | 0513-4870 |
| 其他题名 | 固体药物的转晶现象 |
| 文献子类 | Review |
| 英文摘要 | For the minimized phase transforming risk, the most stable polymorph is generally considered as the desirable solid form for pharmaceutical applications. However, occasionally, the stable form may have some shortcomings such as low solubility, dissolution rate and bioavailability, etc. In that case, the metastable form which is kinetically stable at room or lower temperature could be selected. Using metastable form may result in polymorph transformation in pharmaceutical manufacture and storage. Hence, the knowledge of the transformation between solid forms is essential to the development of the drug materials. In this paper, we will review the recent studies in the area of crystal conversion of polymorphs and hydrates, to illustrate some cases to introduce the types, conditions and mechanisms of the crystalline solid transformation. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5410791 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269284]  |
| 专题 | 药物质量控制与固体化学研究中心 药物安全性评价中心 |
| 通讯作者 | Mei Xuefeng |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200203, China. |
| 推荐引用方式 GB/T 7714 | Zhang Qi,Mei Xuefeng. Polymorph transformation of solid drugs[J]. Acta Pharmaceutica Sinica,2015,50(5):521-527. |
| APA | Zhang Qi,&Mei Xuefeng.(2015).Polymorph transformation of solid drugs.Acta Pharmaceutica Sinica,50(5),521-527. |
| MLA | Zhang Qi,et al."Polymorph transformation of solid drugs".Acta Pharmaceutica Sinica 50.5(2015):521-527. |
入库方式： OAI收割
来源：上海药物研究所
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