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  4. 药物质量控制与固体化学研究中心
Crystal structures and physicochemical properties of amisulpride polymorphs

文献类型：期刊论文

作者Zhang, Wen-Peng1,2; Chen, Dong-Ying1,2
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
出版日期2017-06-05
卷号140页码:252-257
关键词Amisulpride Crystal structure Polymorphism Thermal analysis Hygroscopicity Solubility
ISSN号0731-7085
DOI10.1016/j.jpba.2017.03.030
文献子类Article
英文摘要The purpose of this work was to investigate the crystal structures and physicochemical properties of amisulpride polymorphs. Except of the previously reported polymorph (named as Form I), a new polymorphic form (named as Form II) was discovered through comprehensive solid-state screening experiments. Both polymorphic forms were characterized by single crystal X-ray structure analysis (SXRD), powder X-ray diffraction (PXRD), dynamic vapor sorption (DVS) and thermal analysis (TGA and DSC) as well. It has been found that the Forms I and II are of conformational polymorph with the main conformational difference around ethylsulfonyl group. Form II possesses lower hygroscopicity and better solubility compared with that of Form I, indicating Form II could be an alternate solid form for formulation development. (C) 2017 Elsevier B.V. All rights reserved.
WOS关键词SOLID-STATE ; CHLORAMPHENICOL PALMITATE ; RECEPTOR ANTAGONIST ; LIMBIC SELECTIVITY ; DRUG ; HYDROCHLORIDE ; SCHIZOPHRENIA ; IMPACT ; FORMS
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000402850500030
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/272620]  
专题药物质量控制与固体化学研究中心
通讯作者Chen, Dong-Ying
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Pharmaceut Anal, 555 Rd Zuchongzhi,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Wen-Peng,Chen, Dong-Ying. Crystal structures and physicochemical properties of amisulpride polymorphs[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017,140:252-257.
APA Zhang, Wen-Peng,&Chen, Dong-Ying.(2017).Crystal structures and physicochemical properties of amisulpride polymorphs.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,140,252-257.
MLA Zhang, Wen-Peng,et al."Crystal structures and physicochemical properties of amisulpride polymorphs".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 140(2017):252-257.

入库方式： OAI收割

来源：上海药物研究所

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