Comparison of psychic emergence reactions after (+/-)-ketamine and (+)-ketamine in mice
文献类型：期刊论文
| 作者 | Liu, J ; Ji, XQ; Zhu, XZ
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2006-03-13 |
| 卷号 | 78期号:16页码:1839-1844 |
| 关键词 | ketamine locomotor activity head-twitch response stereotype behavior |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/j.lfs.2005.08.027 |
| 文献子类 | Article |
| 英文摘要 | Ketamine is a racemic mixture containing equal parts of (+)-ketamine and (-)-ketamine. The ketamine enantiomorphs are different in anesthesia and psychic emergence reactions after anesthesia. Therefore, (+)-ketamine was compared with racemic ketamine in a number of randomized studies in volunteers and patients. However, their relations remain controversial. In the present studies, the psychic emergence reactions after injection of (+/-)-ketamine and (+)-ketamine were compared in mice. At equimolar doses, the (+)-isomers elicited episodes of hypnosis nearly 1.4-fold more potent than those of the racemic ketamine. After the administration of equihypnotic doses of (+)ketamine and ketamine, the posthypnotic stimulation of locomotor activity, stereotype behavior and 5-HT-induced head-twitch response by the enantiomorph was significantly less intense than that of racemic ketamine. In receptor binding test, (+)-ketamine showed a higher affinity for NMDA receptor than that of ()-ketamine, while (+)-ketamine and (+/-)-ketamine showed no affinity for dopamine D-2 and serotonin 5-HT, receptor. These results suggest that the (+)-ketamine has fewer posthypnotic side effects than (+/-)-ketamine when (+)-ketamine and (+)-ketamine were administered at equihypnotic dosages and that dopamine D, and serotonin 5-HT, receptor were not involved in the effects of (+)-ketamine and (+/-)-ketamine. (c) 2005 Elsevier Inc. All rights reserved. |
| WOS关键词 | LOCOMOTOR-ACTIVITY ; KETAMINE ; DOPAMINE ; RAT ; PHENCYCLIDINE ; PHARMACOLOGY ; STIMULATION ; MECHANISMS ; RECEPTORS ; SEROTONIN |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000236085800009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273647]  |
| 专题 | 药理学第二研究室 药物发现与设计中心 分析化学研究室 上海药物代谢研究中心 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, J,Ji, XQ,Zhu, XZ. Comparison of psychic emergence reactions after (+/-)-ketamine and (+)-ketamine in mice[J]. LIFE SCIENCES,2006,78(16):1839-1844. |
| APA | Liu, J,Ji, XQ,&Zhu, XZ.(2006).Comparison of psychic emergence reactions after (+/-)-ketamine and (+)-ketamine in mice.LIFE SCIENCES,78(16),1839-1844. |
| MLA | Liu, J,et al."Comparison of psychic emergence reactions after (+/-)-ketamine and (+)-ketamine in mice".LIFE SCIENCES 78.16(2006):1839-1844. |
入库方式： OAI收割
来源：上海药物研究所
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