Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma
文献类型：期刊论文
| 作者 | Zhang, YY; Zhu, HY; Huang, CG ; Cui, XL; Gao, YJ; Huang, Y; Gong, WF; Zhao, Y; Guo, SS
|
| 刊名 | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
 |
| 出版日期 | 2006-02 |
| 卷号 | 47期号:2页码:190-195 |
| 关键词 | astragaloside IV coxsackievirus B3 IFN-gamma viral myocarditis |
| ISSN号 | 0160-2446 |
| DOI | 10.1097/01.fjc.0000199683.43448.64 |
| 文献子类 | Article |
| 英文摘要 | Coxsackievirus B3 (CVB3) is a major pathogen for viral myocarditis and dilated cardiomyopathy in children and young adults. The aim of this study was to determine the antiviral effects of astragaloside IV against CVB3, and the underlying mechanism. First, we evaluated antiviral effects of astragaloside IV in vitro by measuring the virus titers of CVB3 in primarily cultured myocardial cells infected with CVB3, and in vivo by assessing the morbidity, mortality., heart-to-body weight ratio (HW/BW), and virus titers in BALB/c mice infected with CVB3. Then, we performed serum pharmacological experiments by testing the effect of sera from SD rats treated with astragaloside IV on proliferation of CVB3 in primarily cultured myocardial cells. Finally, we determined the effect of astragaloside IV on IFN-gamma rnRNA expression in the hearts of infected BALB/c mice. We observed that astragaloside IV decreased virus titers of CVB3 in primarily cultured myocardial cells. Morbidity, mortality, HW/BW, and virus titers all decreased, and necrosis and mononuclear cell infiltration were alleviated in CVB3-infected mice treated with astragaloside IV, compared with those infiected mice without the treatment. In addition, proliferation of CVB3 was inhibited by the sera of rats treated with astragaloside IV Moreover, we observed that IFN-gamma rnRNA expression was increased in mice treated with astragaloside IV Therefore, we conclude that astragaloside IV exerts antiviral effects against CVB3 by upregulating expression of IFN-gamma mRNA. |
| WOS关键词 | LEFT-VENTRICULAR FUNCTION ; VIRAL MYOCARDITIS ; DNA VACCINE ; B3 ; MICE ; CARDIOMYOPATHY ; PATHOGENESIS ; MEMBRANACEUS ; PROTECTION ; CHALLENGE |
| WOS研究方向 | Cardiovascular System & Cardiology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000235817400006 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273674]  |
| 专题 | 药物发现与设计中心 药物化学研究室 |
| 通讯作者 | Zhang, YY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, YY,Zhu, HY,Huang, CG,et al. Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2006,47(2):190-195. |
| APA | Zhang, YY.,Zhu, HY.,Huang, CG.,Cui, XL.,Gao, YJ.,...&Guo, SS.(2006).Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,47(2),190-195. |
| MLA | Zhang, YY,et al."Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma".JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 47.2(2006):190-195. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。