A computer model for the pore of potassium channel: Oxygen cage mechanism
文献类型：期刊论文
| 作者 | Zhao, SR; Chen, KX ; Tang, Y; Wang, W; Ji, RY
|
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 1997-05 |
| 卷号 | 29期号:3页码:229-234 |
| 关键词 | potassium ion channel molecular modeling pore-forming region membrane protein |
| ISSN号 | 0582-9879 |
| 文献子类 | Article |
| 英文摘要 | We have constructed a structural motif for the pore of voltage-gated Kf channel by computer modeling. The model developed here predicts that the narrowest part of the pore is formed by the four carbonyl oxygens of Gly444 or Gly446, and that the ion selectivity is achieved through ''oxygen cage'' mechanism. Residues 447,448 and 449 make the external entrance to the narrowest part of the pore. Of these residues, 449 and 447 are believed to interact directly with TEA. This model agrees well with many available experimental data. |
| WOS关键词 | SHAKER K+ CHANNEL ; RESIDUES ; CHARYBDOTOXIN ; INHIBITOR ; PEPTIDE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 中文 |
| CSCD记录号 | CSCD:392329 |
| WOS记录号 | WOS:A1997XZ28400002 |
| 出版者 | SHANGHAI INST BIOCHEMISTRY, ACADEMIA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274910]  |
| 专题 | 药物发现与设计中心 药理学第二研究室 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Zhao, SR,Chen, KX,Tang, Y,et al. A computer model for the pore of potassium channel: Oxygen cage mechanism[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,1997,29(3):229-234. |
| APA | Zhao, SR,Chen, KX,Tang, Y,Wang, W,&Ji, RY.(1997).A computer model for the pore of potassium channel: Oxygen cage mechanism.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,29(3),229-234. |
| MLA | Zhao, SR,et al."A computer model for the pore of potassium channel: Oxygen cage mechanism".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 29.3(1997):229-234. |
入库方式： OAI收割
来源：上海药物研究所
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