Study on the Quantitative Structure-activity Relationship of N-1 Position of Quinolone
文献类型：期刊论文
| 作者 | Zhu Longguan1; Yu Qingsen1; Chen Kaixian2 ; Cai Cuoqiang1; Lin Ruisen1
|
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 1995 |
| 卷号 | 11期号:10页码:925-928 |
| 关键词 | Fluoroquinolone QSAR CoMFA |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB19951014 |
| 文献子类 | Article |
| 英文摘要 | The steric and electrostatic effects of N-1 substituted groups of fluoroquinolones and the way to find the new group with high activities by Comparative Molecular Field Analysis (CoMFA) have been studied. The results indicated that (1) The activity of N-1 position was mainly determinted by the steric effect, but the electrostatic effect is also important, (2) No new N-1 substituted group with higher activity was found from the coefficient plots of CoMFA, which reflected the experimental results of late of years. |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:282511 |
| WOS记录号 | WOS:000207590900013 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275074]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Zhu Longguan |
| 作者单位 | 1.Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu Longguan,Yu Qingsen,Chen Kaixian,et al. Study on the Quantitative Structure-activity Relationship of N-1 Position of Quinolone[J]. ACTA PHYSICO-CHIMICA SINICA,1995,11(10):925-928. |
| APA | Zhu Longguan,Yu Qingsen,Chen Kaixian,Cai Cuoqiang,&Lin Ruisen.(1995).Study on the Quantitative Structure-activity Relationship of N-1 Position of Quinolone.ACTA PHYSICO-CHIMICA SINICA,11(10),925-928. |
| MLA | Zhu Longguan,et al."Study on the Quantitative Structure-activity Relationship of N-1 Position of Quinolone".ACTA PHYSICO-CHIMICA SINICA 11.10(1995):925-928. |
入库方式： OAI收割
来源：上海药物研究所
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