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Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system

文献类型:期刊论文

作者Zou, Kun1,2; Li, Zhao1,2; Zhang, Yong2; Zhang, Hao-yue1,2; Li, Bo2; Zhu, Wei-liang2; Shi, Ji-ye3,4; Jia, Qi1; Li, Yi-ming1
刊名ACTA PHARMACOLOGICA SINICA
出版日期2017-02
卷号38期号:2页码:157-167
关键词berberine natural product anti-inflammatory drug anticancer drug digestive system structure-activity relationship
ISSN号1671-4083
DOI10.1038/aps.2016.125
文献子类Review
英文摘要It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic with a long history. Over the past decade, many reports have demonstrated that this natural product and its derivatives have high activity against both cancer and inflammation. In this review, we summarize the advances in studing berberine and its derivatives as anti-inflammatory and anti-tumor agents in the digestive system; we also discuss their structure-activity relationship. These data should be useful for the development of this natural product as novel anticancer drugs with anti-inflammation activity.
WOS关键词NF-KAPPA-B ; TUMOR-NECROSIS-FACTOR ; HUMAN HEPATOMA-CELLS ; IN-VITRO ; NASOPHARYNGEAL CARCINOMA ; CANCER-CELLS ; COLON-CANCER ; TNF-ALPHA ; HEPATOCELLULAR-CARCINOMA ; ALKALOID BERBERINE
资助项目Natural Science Foundation of Shanghai, China[14ZR1447800] ; Natural Science Foundation of Shanghai, China[15ZR1441200] ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines[GTZK201606]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:5906826
WOS记录号WOS:000393013400001
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/275658]  
专题药物发现与设计中心
通讯作者Li, Bo; Shi, Ji-ye; Jia, Qi
作者单位1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
3.UCB Biopharma SPRL, Chemin Foriest, Braine Lalleud, Belgium;
4.Univ Oxford, Kellogg Coll, Oxford OX2 6PN, England
推荐引用方式
GB/T 7714
Zou, Kun,Li, Zhao,Zhang, Yong,et al. Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system[J]. ACTA PHARMACOLOGICA SINICA,2017,38(2):157-167.
APA Zou, Kun.,Li, Zhao.,Zhang, Yong.,Zhang, Hao-yue.,Li, Bo.,...&Li, Yi-ming.(2017).Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system.ACTA PHARMACOLOGICA SINICA,38(2),157-167.
MLA Zou, Kun,et al."Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system".ACTA PHARMACOLOGICA SINICA 38.2(2017):157-167.

入库方式: OAI收割

来源:上海药物研究所

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