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Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system
文献类型：期刊论文
| 作者 | Zou, Kun1,2; Li, Zhao1,2; Zhang, Yong2; Zhang, Hao-yue1,2; Li, Bo2; Zhu, Wei-liang2 ; Shi, Ji-ye3,4; Jia, Qi1; Li, Yi-ming1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2017-02 |
| 卷号 | 38期号:2页码:157-167 |
| 关键词 | berberine natural product anti-inflammatory drug anticancer drug digestive system structure-activity relationship |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2016.125 |
| 文献子类 | Review |
| 英文摘要 | It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic with a long history. Over the past decade, many reports have demonstrated that this natural product and its derivatives have high activity against both cancer and inflammation. In this review, we summarize the advances in studing berberine and its derivatives as anti-inflammatory and anti-tumor agents in the digestive system; we also discuss their structure-activity relationship. These data should be useful for the development of this natural product as novel anticancer drugs with anti-inflammation activity. |
| WOS关键词 | NF-KAPPA-B ; TUMOR-NECROSIS-FACTOR ; HUMAN HEPATOMA-CELLS ; IN-VITRO ; NASOPHARYNGEAL CARCINOMA ; CANCER-CELLS ; COLON-CANCER ; TNF-ALPHA ; HEPATOCELLULAR-CARCINOMA ; ALKALOID BERBERINE |
| 资助项目 | Natural Science Foundation of Shanghai, China[14ZR1447800] ; Natural Science Foundation of Shanghai, China[15ZR1441200] ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines[GTZK201606] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5906826 |
| WOS记录号 | WOS:000393013400001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275658]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Li, Bo; Shi, Ji-ye; Jia, Qi |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.UCB Biopharma SPRL, Chemin Foriest, Braine Lalleud, Belgium; 4.Univ Oxford, Kellogg Coll, Oxford OX2 6PN, England |
| 推荐引用方式 GB/T 7714 | Zou, Kun,Li, Zhao,Zhang, Yong,et al. Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system[J]. ACTA PHARMACOLOGICA SINICA,2017,38(2):157-167. |
| APA | Zou, Kun.,Li, Zhao.,Zhang, Yong.,Zhang, Hao-yue.,Li, Bo.,...&Li, Yi-ming.(2017).Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system.ACTA PHARMACOLOGICA SINICA,38(2),157-167. |
| MLA | Zou, Kun,et al."Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system".ACTA PHARMACOLOGICA SINICA 38.2(2017):157-167. |
入库方式： OAI收割
来源：上海药物研究所
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