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Design, Synthesis, and Structure-Activity Relationships of Bavachinin Analogues as Peroxisome Proliferator-Activated Receptor Agonists

文献类型：期刊论文

作者Du, Guoxin2; Zhao, Yuanyuan2; Feng, Li2; Yang, Zhuo1,4; Shi, Jiye3; Huang, Cheng2; Li, Bo1,4; Guo, Fujiang2; Zhu, Weiliang1,4; Li, Yiming2
刊名CHEMMEDCHEM
出版日期2017-01-20
卷号12期号:2页码:183-193
关键词bavachinin diabetes mellitus PPAR reporter gene assays structure-activity relationships
ISSN号1860-7179
DOI10.1002/cmdc.201600554
文献子类Article
英文摘要Peroxisome proliferator-activated receptor (PPAR) agonists have been used for the treatment of diabetes with the effect of lowering blood glucose levels and improving insulin sensitivity. Natural compounds such as flavones, flavanones, and isoflavones have shown excellent PPAR agonist activity. In this study, analogues of bavachinin were designed, synthesized, and evaluated by reporter gene assays for PPAR agonist activity. Preliminary structure-activity relationships for these bavachinin analogues have been summarized, and seven compounds were found to have higher PPAR agonist activities than the parent flavanone bavachinin.
WOS关键词PPAR-GAMMA AGONISTS ; PSORALEA-CORYLIFOLIA ; DIABETES-MELLITUS ; DERIVATIVES ; POTENT ; INHIBITORS ; CHALCONES ; METABOLISM ; FLAVONOIDS ; ALPHA
资助项目Excellent Academic Leaders Program of Shanghai[16XD1403500] ; Shanghai Science and Technology Committee[16401902000] ; Natural Science Foundation of Shanghai, China[14ZR1447800] ; Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine[00000000]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000394582200007
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/275670]  
专题药物发现与设计中心
通讯作者Li, Bo; Guo, Fujiang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
2.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China;
3.UCB Pharma, Dept Informat, 216 Bath Rd, Slough SL1 4EN, Berks, England
4.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Du, Guoxin,Zhao, Yuanyuan,Feng, Li,et al. Design, Synthesis, and Structure-Activity Relationships of Bavachinin Analogues as Peroxisome Proliferator-Activated Receptor Agonists[J]. CHEMMEDCHEM,2017,12(2):183-193.
APA Du, Guoxin.,Zhao, Yuanyuan.,Feng, Li.,Yang, Zhuo.,Shi, Jiye.,...&Li, Yiming.(2017).Design, Synthesis, and Structure-Activity Relationships of Bavachinin Analogues as Peroxisome Proliferator-Activated Receptor Agonists.CHEMMEDCHEM,12(2),183-193.
MLA Du, Guoxin,et al."Design, Synthesis, and Structure-Activity Relationships of Bavachinin Analogues as Peroxisome Proliferator-Activated Receptor Agonists".CHEMMEDCHEM 12.2(2017):183-193.

入库方式： OAI收割

来源：上海药物研究所

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