Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway
文献类型：期刊论文
| 作者 | Chang, Gaomei2,3; Xiao, Wenqin3; Xu, Zhijian1,4 ; Yu, Dandan3; Li, Bo; Zhang, Yong1; Sun, Xi3; Xie, Yongsheng3; Chang, Shuaikang3; Gao, Lu3
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| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2017 |
| ISSN号 | 2314-6133 |
| DOI | 10.1155/2017/9872073 |
| 文献子类 | Article |
| 英文摘要 | Pterostilbene is a natural 3,5-dimethoxy analog of trans-resveratrol that has been reported to have antitumor, antioxidant, and anti-inflammatory effects. T-cell leukemia/lymphoma is one of the more aggressive yet uncommon non-Hodgkin lymphomas. Although there has been increasing research into T-cell leukemia/lymphoma, the molecular mechanisms of the antitumor effects of pterostilbene against this malignancy are still largely unknown. The aim of this study is to confirm the effects of pterostilbene in T-cell leukemia/lymphoma. Jurkat and Hut-78 cells treated with pterostilbene were evaluated for cell proliferation using Cell Counting Kit-8, and apoptosis, cell cycle progression, reactive oxygen species generation, and mitochondrial membrane potential were analyzed using flow cytometry. The level of protein expression was detected by western blot. The results demonstrated that pterostilbene significantly inhibited the growth of T-cell leukemia/lymphoma cell lines in vitro and induced apoptosis in a dose-and time-dependent manner. Moreover, pterostilbene treatment markedly induced S-phase cell cycle arrest, which was accompanied by downregulation of cdc25A, cyclin A2, and CDK2. Pterostilbene also induced the generation of reactive oxygen species and the loss of mitochondrial membrane potential and inhibited ERK1/2 phosphorylation. Taken together, our study demonstrated the potential of pterostilbene to be an effective treatment for T-cell leukemia/lymphoma. |
| WOS关键词 | CANCER CELLS ; IN-VITRO ; RESVERATROL ; ANTIOXIDANT ; INHIBITORS ; AUTOPHAGY ; LYMPHOMA ; LEUKEMIA |
| 资助项目 | National Natural Science Foundation of China[81570190] ; National Natural Science Foundation of China[81372391] ; National Natural Science Foundation of China[81529001] ; National Natural Science Foundation of China[31271496] ; Nankai University's State Key Laboratory of Medicinal Chemical Biology funds[201602010] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000405819700001 |
| 出版者 | HINDAWI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275707]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Zhu, Weiliang; Shi, Jumei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Anhui Med Univ, Dept Hematol, Hefei 230032, Peoples R China; 3.Tongji Univ, Shanghai Peoples Hosp 10, Dept Hematol, Sch Med, Shanghai 200072, Peoples R China; 4.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China; 5.Tongji Univ, Coll Life Sci & Technol, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Gaomei,Xiao, Wenqin,Xu, Zhijian,et al. Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway[J]. BIOMED RESEARCH INTERNATIONAL,2017. |
| APA | Chang, Gaomei.,Xiao, Wenqin.,Xu, Zhijian.,Yu, Dandan.,Li, Bo.,...&Shi, Jumei.(2017).Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway.BIOMED RESEARCH INTERNATIONAL. |
| MLA | Chang, Gaomei,et al."Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway".BIOMED RESEARCH INTERNATIONAL (2017). |
入库方式： OAI收割
来源：上海药物研究所
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