Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells
文献类型：期刊论文
| 作者 | Kong, Yuanyuan2; Chen, Gege2; Xu, Zhijian3 ; Yang, Guang2; Li, Bo3; Wu, Xiaosong2; Xiao, Wenqin2; Xie, Bingqian2; Hu, Liangning2; Sun, Xi2
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-11-21 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep37417 |
| 文献子类 | Article |
| 英文摘要 | Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo. We found that pterostilbene treatment resulted in a dose-dependent inhibition of cell viability. In addition, pterostilbene exhibited a strong cytotoxic effect, as evidenced not only by reductions of mitochondrial membrane potential (MMP) but also by increases in cellular apoptotic index and reactive oxygen species (ROS) levels, leading to arrest in the S-phase of the cell cycle. Furthermore, pterostilbene treatment directly up-regulated p-p38MAPK and downregulated p-ERK1/2. In vivo, intravenous administration of pterostilbene inhibited tumor development in xenograft mouse models. Overall, the results suggested that pterostilbene is a potential anti-cancer pharmaceutical against human DLBCL by a mechanism involving the suppression of ERK1/2 and activation of p38MAPK signaling pathways. |
| WOS关键词 | COLON-CANCER CELLS ; LEUKEMIA-CELLS ; CARCINOMA CELLS ; RESVERATROL ; EXPRESSION ; GENE ; BLUEBERRIES ; CARCINOGENESIS ; CONSTITUENT ; ANTICANCER |
| 资助项目 | National Natural Science Foundation of China[81372391] ; National Natural Science Foundation of China[31271496] ; National Natural Science Foundation of China[81300443] ; National Natural Science Foundation of China[81570190] ; National Natural Science Foundation of China[81529001] ; National Natural Science Foundation of China[81302699] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000388196200001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275802]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Tao, Yi; Zhu, Weiliang; Shi, Jumei |
| 作者单位 | 1.Tongji Univ, Coll Life Sci & Technol, Shanghai 200092, Peoples R China 2.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Hematol, Shanghai 200072, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Kong, Yuanyuan,Chen, Gege,Xu, Zhijian,et al. Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Kong, Yuanyuan.,Chen, Gege.,Xu, Zhijian.,Yang, Guang.,Li, Bo.,...&Shi, Jumei.(2016).Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells.SCIENTIFIC REPORTS,6. |
| MLA | Kong, Yuanyuan,et al."Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。