Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Xie, Bingqian1; Xu, Zhijian2 ; Hu, Liangning1; Chen, Gege1; Wei, Rong1; Yang, Guang1; Li, Bo2; Chang, Gaomei1; Sun, Xi1; Wu, Huiqun1
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2016-11 |
| 卷号 | 17期号:11 |
| 关键词 | multiple myeloma pterostilbene apoptosis cell cycle ERK1/2 JNK |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms17111927 |
| 文献子类 | Article |
| 英文摘要 | Multiple myeloma (MM) is the second most common malignancy in the hematologic system, which is characterized by accumulation of plasma cells in bone marrow. Pterostilbene (PTE) is a natural dimethylated analog of resveratrol, which has anti-oxidant, anti-inflammatory and anti-tumor properties. In the present study, we examined the anti-tumor effect of PTE on MM cell lines both in vitro and in vivo using the cell counting kit (CCK)-8, apoptosis assays, cell cycle analysis, reactive oxygen species (ROS) generation, JC-1 mitochondrial membrane potential assay, Western blotting and tumor xenograft models. The results demonstrated that PTE induces apoptosis in the H929 cell line and causes cell cycle arrest at G0/G1 phase by enhancing ROS generation and reducing mitochondrial membrane potential. The anti-tumor effect of PTE may be caused by the activation of the extracellular regulated protein kinases (ERK) 1/2 and c-Jun N-terminal kinase (JNK) signaling pathways. Additionally, mice treated with PTE by intraperitoneal injection demonstrated reduced tumor volume. Taken together, the results of this study indicate that the anti-tumor effect of PTE on MM cells may provide a new therapeutic option for MM patients. |
| WOS关键词 | NEGATIVE BREAST-CANCER ; DNA-DAMAGE RESPONSE ; NF-KAPPA-B ; INDUCED APOPTOSIS ; RESVERATROL ; RESISTANCE ; EXPRESSION ; ARREST ; LINE ; LEUKEMIA |
| 资助项目 | National Natural Science Foundation of China[81372391] ; National Natural Science Foundation of China[81570190] ; National Natural Science Foundation of China[81529001] ; National Natural Science Foundation of China[81302699] ; National Natural Science Foundation of China[31271496] ; National Natural Science Foundation of China[81600174] ; National Natural Science Foundation of China[81300443] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000388809600156 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275827]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Tao, Yi; Shi, Jumei; Zhu, Weiliang |
| 作者单位 | 1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Hematol, Shanghai 200072, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Tongji Univ, Coll Life Sci & Technol, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Bingqian,Xu, Zhijian,Hu, Liangning,et al. Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(11). |
| APA | Xie, Bingqian.,Xu, Zhijian.,Hu, Liangning.,Chen, Gege.,Wei, Rong.,...&Zhu, Weiliang.(2016).Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(11). |
| MLA | Xie, Bingqian,et al."Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.11(2016). |
入库方式： OAI收割
来源：上海药物研究所
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