Thermodynamic and kinetic investigation of agomelatine polymorph transformation
文献类型：期刊论文
| 作者 | Zhang, Qi; Jiang, Linglei; Mei, Xuefeng
|
| 刊名 | PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
 |
| 出版日期 | 2016-02-17 |
| 卷号 | 21期号:2页码:196-203 |
| 关键词 | Activation energy kinetic phase transformation polymorph |
| ISSN号 | 1083-7450 |
| DOI | 10.3109/10837450.2014.982824 |
| 文献子类 | Article |
| 英文摘要 | Thermodynamic properties of polymorphic forms I and II of Agomelatine were investigated and the bimorphism was determined to be monotropically related. The phase transition kinetics from metastable form I to thermodynamically stable form II was studied and a quantification method was developed based on X-ray powder diffraction technique. Various solid-state kinetic models were examined and the results were fit to the experimental data. The nucleation kinetic models were found to be the best fit to describe the experimental data across the temperature range. The activation energy of the form transformation was calculated in the range of 116-122kJmol(-1), irrespective of which kinetic model selected. |
| WOS关键词 | TRANSITIONS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000368680100009 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276143]  |
| 专题 | 药物质量控制与固体化学研究中心 药物安全性评价中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, 555 Zu Chong Zhi Rd,Zhang Jiang High Tech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qi,Jiang, Linglei,Mei, Xuefeng. Thermodynamic and kinetic investigation of agomelatine polymorph transformation[J]. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY,2016,21(2):196-203. |
| APA | Zhang, Qi,Jiang, Linglei,&Mei, Xuefeng.(2016).Thermodynamic and kinetic investigation of agomelatine polymorph transformation.PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY,21(2),196-203. |
| MLA | Zhang, Qi,et al."Thermodynamic and kinetic investigation of agomelatine polymorph transformation".PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 21.2(2016):196-203. |
入库方式： OAI收割
来源：上海药物研究所
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