Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities
文献类型：期刊论文
| 作者 | Zhang, Xu3,6; Ba, Qian4,5; Gu, Zhanni3,6; Guo, Diliang3,6; Zhou, Yu3 ; Xu, Yungen6; Wang, Hui4,5; Ye, Deju1,2; Liu, Hong3,6
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| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
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| 出版日期 | 2015-11-23 |
| 卷号 | 21期号:48页码:17415-17421 |
| 关键词 | apoptosis cancer drug delivery imaging agents theranostic probes |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201502543 |
| 文献子类 | Article |
| 英文摘要 | Mitochondria-targeting theranostic probes that enable the simultaneously reporting of and triggering of mitochondrial dysfunctions in cancer cells are highly attractive for cancer diagnosis and therapy. Three fluorescent mitochondria-targeting theranostic probes have been developed by linking a mitochondrial dye, coumarin-3-carboximide, with a widely used traditional Chinese medicine, artemisinin, to kill cancer cells. Fluorescence images showed that the designed coumarin artemisinin conjugates localized mainly in mitochondria, leading to enhanced anticancer activities over artemisinin. High cytotoxicity against cancer cells correlated with the strong ability to accumulate in mitochondria, which could efficiently increase the intracellular reactive oxygen species level and induce cell apoptosis. This study highlights the potential of using mitochondria targeting fluorophores to selectively trigger and directly visualize subcellular drug delivery in living cells. |
| WOS关键词 | AGGREGATION-INDUCED-EMISSION ; CANCER-THERAPY ; PLASMODIUM-FALCIPARUM ; ANTIMALARIAL ACTIVITY ; GEMCITABINE DELIVERY ; OXIDATIVE STRESS ; CELL-DEATH ; IN-VIVO ; MECHANISM ; NANOPARTICLES |
| 资助项目 | National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[21327902] ; National Natural Science Foundation of China[81125020] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015C8910304] ; National High Technology Research and Development Program of China[2012AA020302] ; Science and Technology Commission of Shanghai Municipality[12431900500] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000366510900035 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276315]  |
| 专题 | 药物化学研究室 药物发现与设计中心 药理学第一研究室 |
| 通讯作者 | Wang, Hui |
| 作者单位 | 1.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 270093, Jiangsu, Peoples R China; 2.Nanjing Univ, Collaborat Innovat Ctr Chem Life Sci, Sch Chem & Chem Engn, Nanjing 270093, Jiangsu, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China; 5.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China; 6.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xu,Ba, Qian,Gu, Zhanni,et al. Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities[J]. CHEMISTRY-A EUROPEAN JOURNAL,2015,21(48):17415-17421. |
| APA | Zhang, Xu.,Ba, Qian.,Gu, Zhanni.,Guo, Diliang.,Zhou, Yu.,...&Liu, Hong.(2015).Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities.CHEMISTRY-A EUROPEAN JOURNAL,21(48),17415-17421. |
| MLA | Zhang, Xu,et al."Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities".CHEMISTRY-A EUROPEAN JOURNAL 21.48(2015):17415-17421. |
入库方式： OAI收割
来源：上海药物研究所
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