Insight into the conformational polymorph transformation of a block-buster multiple sclerosis drug fingolimod hydrochloride (FTY 720)
文献类型：期刊论文
| 作者 | Wang, Jian-Rong ; Li, Sha; Zhu, Bingqing; Mei, Xuefeng
|
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2015-05-10 |
| 卷号 | 109页码:45-51 |
| 关键词 | Fingolimod hydrochloride Conformational polymorphism Single-crystal to single-crystal Thermal analysis Polymorph transformation |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2015.02.018 |
| 文献子类 | Article |
| 英文摘要 | Single-crystal structures of fingolimod hydrochloride (FTY 720), a block-buster multiple sclerosis drug, were revealed for the first time in this study. Three different conformational polymorphs (designated as forms I-III) were characterized using a variety of analytical techniques, including single-crystal XRD, VT-PXRD, DSC, HSM, and VT-confocal Raman spectroscopy. A temperature-dependent solid-solid transformation between different conformational polymorphs was observed to be reversible, and the transition process was studied using both VT-PXRD and VT-Raman techniques. Structural analysis revealed that the FTY 720 molecules adopt distinctive conformations in different polymorphs. Single-crystal to single-crystal transformation from form I to II was observed and was closely monitored by X-ray diffraction. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | DIFFERENTIAL SCANNING CALORIMETRY ; RAMAN-SPECTROSCOPY ; FORMS |
| 资助项目 | National Natural Science Foundation of China[81273479] ; National Natural Science Foundation of China[81402898] ; Shanghai Institute of Materia Medica New-Star Plan B[00000000] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000353078700006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276532]  |
| 专题 | 药物质量控制与固体化学研究中心 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jian-Rong,Li, Sha,Zhu, Bingqing,et al. Insight into the conformational polymorph transformation of a block-buster multiple sclerosis drug fingolimod hydrochloride (FTY 720)[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2015,109:45-51. |
| APA | Wang, Jian-Rong,Li, Sha,Zhu, Bingqing,&Mei, Xuefeng.(2015).Insight into the conformational polymorph transformation of a block-buster multiple sclerosis drug fingolimod hydrochloride (FTY 720).JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,109,45-51. |
| MLA | Wang, Jian-Rong,et al."Insight into the conformational polymorph transformation of a block-buster multiple sclerosis drug fingolimod hydrochloride (FTY 720)".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 109(2015):45-51. |
入库方式： OAI收割
来源：上海药物研究所
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